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1. WO2022008699 - CONCENTRATED COMPOSITIONS OF PROTEINS, THEIR PREPARATION AND USE THEREOF

Publication Number WO/2022/008699
Publication Date 13.01.2022
International Application No. PCT/EP2021/069090
International Filing Date 09.07.2021
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61K 47/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, WS, ZA, ZM, ZW)
  • HOFFMANN-LA ROCHE INC. [US]/[US] (US)
Inventors
  • DAHMANA, Naoual
  • FACCHETTI, Samantha, Veronica
  • MARIN, Zana
  • PATEL, Sulabh, Pravinchandra
  • SCHWACH, Gregoire
Agents
  • MARCHAND, Philipp
Priority Data
20184997.309.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CONCENTRATED COMPOSITIONS OF PROTEINS, THEIR PREPARATION AND USE THEREOF
(FR) COMPOSITIONS CONCENTRÉES DE PROTÉINES, LEUR PRÉPARATION ET L'UTILISATION ASSOCIÉE
Abstract
(EN) The invention relates to a method for producing a composition comprising reversible protein complexes (RPCs), the method comprising the steps of contacting a protein and a complexing agent in a buffer solution, wherein the complexing agent is dextran sulphate or chondroitin sulphate, and wherein the protein and the complexing agent have opposite net charges when comprised in the buffer solution; formation of RPCs between the protein and the complexing agent in the buffer solution; and obtaining a suspension comprising the RPCs. Provided herein are also compositions, including pharmaceutical compositions/ formulations comprising the reversible protein complexes (RPCs) of the invention, in particular as obtained by the method provided herein.
(FR) La présente invention concerne un procédé destiné à la fabrication d'une composition comprenant des complexes protéiques réversibles (RPC), le procédé comprenant les étapes consistant à mettre en contact une protéine et un agent complexant dans une solution tampon, l'agent complexant étant du sulfate de dextrane ou du sulfate de chondroïtine et la protéine et l'agent complexant présentant des charges nettes opposées lorsqu'ils sont compris dans la solution tampon ; la formation des RPC entre la protéine et l'agent complexant dans la solution tampon ; et en l'obtention d'une suspension comprenant les RPC. L'invention concerne également des compositions, notamment des compositions/formulations pharmaceutiques consistant en les complexes de protéines réversibles (RPC) de l'invention, en particulier tels qu'obtenus par le procédé décrit dans la description.
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