Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022008687 - AN IMPROVED MEASLES VIRUS VACCINE VECTOR BASED ON MULTIPLE TANDEM ADDITIONAL TRANSCRIPTION UNITS (ATUS)

Publication Number WO/2022/008687
Publication Date 13.01.2022
International Application No. PCT/EP2021/069070
International Filing Date 08.07.2021
IPC
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C12N 15/86 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Applicants
  • INSTITUT PASTEUR [FR]/[FR]
Inventors
  • NAMPRACHAN-FRANTZ, Phanramphoei
  • TANGY, Frédéric
  • COMBREDET, Chantal
  • GRACIAS, Ségolène
Agents
  • ERNEST GUTMANN - YVES PLASSERAUD SAS
Priority Data
20305789.808.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AN IMPROVED MEASLES VIRUS VACCINE VECTOR BASED ON MULTIPLE TANDEM ADDITIONAL TRANSCRIPTION UNITS (ATUS)
(FR) VECTEUR DE VACCIN CONTRE LE VIRUS DE LA ROUGEOLE AMÉLIORÉ BASÉ SUR DE MULTIPLES UNITÉS DE TRANSCRIPTION SUPPLÉMENTAIRES EN TANDEM (ATUS)
Abstract
(EN) The application generally relates to enhanced recombinant nucleic acid constructs comprising a cDNA molecule encoding a full length antigenomic (+) RNA strand of a non-segmented negative-sense single-stranded RNA virus for expressing at least one heterologous polypeptide, protein, antigen, or antigenic fragment thereof. The application more particularly relates to constructs with multiple ATUs localized within a single intergenic region of a virus. The application also relates to the association between a construct with multiple ATUs and BAG plasmid to facilitate the introduction and expression of large inserts.
(FR) L'invention concerne d'une manière générale des constructions améliorées d'acides nucléiques recombinants comprenant une molécule d'ADNc codant pour un brin d'ARN (+) antigénomique pleine longueur d'un virus à ARN monocaténaire sens négatif non segmenté pour exprimer au moins un polypeptide hétérologue, une protéine, un antigène ou un fragment d'antigène de celui-ci. L'invention concerne plus particulièrement des constructions ayant de multiples ATU localisés dans une région intergénique unique d'un virus. L'invention concerne également l'association entre une construction avec des plasmides multiples ATU et BAG pour faciliter l'introduction et l'expression de grands inserts.
Related patent documents
Latest bibliographic data on file with the International Bureau