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1. WO2022008657 - EXTRACELLULAR VESICLES AND COMPOSITIONS THEREOF

Publication Number WO/2022/008657
Publication Date 13.01.2022
International Application No. PCT/EP2021/068997
International Filing Date 08.07.2021
IPC
A61K 35/28 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61P 1/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C12N 5/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants
  • EXO BIOLOGICS SA [BE]/[BE]
Inventors
  • JURGA, Marcin
Agents
  • BRANTSANDPATENTS BVBA
Priority Data
20184917.109.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) EXTRACELLULAR VESICLES AND COMPOSITIONS THEREOF
(FR) VÉSICULES EXTRACELLULAIRES ET LEURS COMPOSITIONS
Abstract
(EN) The current invention relates to a composition comprising extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs), said EVs are part of a population of particles in said composition having a particle size of between 0.05 and 0.22 micron, said concentration of these particles is at least 1 x 1011 particles per ml of composition and wherein at least 90% of said particles with particle size of between 0.05 and 0.22 micron are EVs, said EVs are defined by having a concentration of intra-vesicular Annexin V of at least 40 ng/ml and a concentration of extra-vesicular Annexin V of less than 1 ng/ml. The current invention also relates to the use such composition.
(FR) La présente invention concerne une composition comprenant des vésicules extracellulaires (EV) dérivées de cellules stromales mésenchymateuses (MSC), lesdites EV font partie d'une population de particules dans ladite composition ayant une taille de particule comprise entre 0,05 et 0,22 micron, ladite concentration de ces particules est d'au moins 1 x 1011 particules par ml de composition et au moins 90 % desdites particules ayant une taille de particule comprise entre 0,05 et 0,22 micron sont des EV, lesdites EV sont définies en ce qu'elles présentent une concentration d'annexine V intra-vésiculaire d'au moins 40 ng/ml et une concentration d'annexine V extra-vésiculaire inférieure à 1 ng/ml. L'invention concerne également l'utilisation de telles compositions.
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