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1. WO2022008639 - ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES

Publication Number WO/2022/008639
Publication Date 13.01.2022
International Application No. PCT/EP2021/068951
International Filing Date 08.07.2021
IPC
C07D 239/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
20having two double bonds between ring members or between ring members and non-ring members
22with hetero atoms directly attached to ring carbon atoms
C07D 405/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 493/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
08Bridged systems
A61P 33/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
A61K 31/513 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
Applicants
  • UCB BIOPHARMA SRL [BE]/[BE]
Inventors
  • DE HARO GARCIA, Teresa
  • FROST, James Richard
  • LALLEMAND, Bénédicte
  • LOWE, Martin Alexander
Agents
  • UCB INTELLECTUAL PROPERTY
Priority Data
2010606.810.07.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES
(FR) ANALOGUES D'HEXAHYDROPYRIMIDINE ANTIPALUDIQUES
Abstract
(EN) The application relates to 2-imino-hexahydropyrimidin-4-one derivatives of formula (I) which are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful for the treatment of malaria.
(FR) L'invention concerne des dérivés de 2-imino-hexahydropyrimidine-4-one de formule (I) qui sont des inhibiteurs puissants de la croissance et de la propagation du parasite Plasmodium falciparum dans le sang humain et donc utiles pour le traitement du paludisme.
Latest bibliographic data on file with the International Bureau