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1. WO2022008628 - METHOD FOR PREPARATION OF 2,6-BIS(HYDROXYMETHYL)PYRIDINE VIA ENZYMATIC CATALYSIS

Publication Number WO/2022/008628
Publication Date 13.01.2022
International Application No. PCT/EP2021/068920
International Filing Date 07.07.2021
IPC
C12P 13/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
C12P 17/12 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
12containing a six-membered hetero ring
C07D 213/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
C12N 9/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
Applicants
  • VIO CHEMICALS AG [CH]/[CH]
Inventors
  • PANKE, Sven
  • HELD, Martin
  • KARDASHLIEV, Tsvetan
Agents
  • PATENTNI BIRO AF D.O.O.
Priority Data
PCT/EP2020/02532107.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARATION OF 2,6-BIS(HYDROXYMETHYL)PYRIDINE VIA ENZYMATIC CATALYSIS
(FR) PROCÉDÉ DE PRÉPARATION DE 2,6-BIS (HYDROXYMÉTHYL)PYRIDINE PAR CATALYSE ENZYMATIQUE
Abstract
(EN) The present invention relates to the provision of an enzymatic method for the preparation of 2, 6-bis(hydroxymethyl) pyridine (Formula I) using as substrate 2,6-Dimethlypyridine (2,6-lutidene) and the multicomponent xylene monooxygenase comprising XylM and XylA from Pseudomonas putida (Arthrobacter siderocapsulatus). The enzymatic method of the present invention is advantageous over conventional synthetic preparations, providing access to the title compound with a one-step enzymatic procedure.
(FR) La présente invention concerne la mise à disposition d'un procédé enzymatique pour la préparation de la 2,6-bis(hydroxyméthyl)pyridine (formule I) en utilisant comme substrat la 2,6-diméthlypyridine (2,6-lutidène) et la xylène monooxygénase multicomposante comprenant XylM et XylA de Pseudomonas putida (Arthrobacter siderocapsulatus). Le procédé enzymatique de la présente invention est avantageux par rapport aux préparations synthétiques classiques, fournissant un accès au composé de titre avec une procédure enzymatique en une étape.
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