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1. WO2022008627 - IMPROVED METHOD FOR THE PRODUCTION OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND NOVEL DERIVATIVES THEREOF

Publication Number WO/2022/008627
Publication Date 13.01.2022
International Application No. PCT/EP2021/068919
International Filing Date 07.07.2021
IPC
C07D 457/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
457Heterocyclic compounds containing indolo quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid
04with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
06Lysergic acid amides
C07D 457/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
457Heterocyclic compounds containing indolo quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid
04with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
06Lysergic acid amides
08in which the amide nitrogen is a member of a heterocyclic ring
C07D 519/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61P 25/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61K 31/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
48Ergoline derivatives, e.g. lysergic acid, ergotamine
CPC
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
C07D 457/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
457Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid
04with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
06Lysergic acid amides
C07D 457/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
457Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula: , e.g. lysergic acid
04with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
06Lysergic acid amides
08in which the amide nitrogen is a member of a heterocyclic ring
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • COMPASS PATHFINDER LIMITED [GB]/[GB]
Inventors
  • GRILL, Matthias
Agents
  • MARCHAND, Philipp
Priority Data
10 2020 117 924.307.07.2020DE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED METHOD FOR THE PRODUCTION OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND NOVEL DERIVATIVES THEREOF
(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRODUCTION DE DIÉTHYLAMIDE D'ACIDE LYSERGIQUE (LSD) ET NOUVEAUX DÉRIVÉS ASSOCIÉS
Abstract
(EN) The present invention provides an improved method for the production of lysergic acid diethylamide (LSD) for GMP purposes. Furthermore, the present invention provides novel LSD derivatives of formula (I) as well as their synthesis and purification. Due to the affinity of the presented substances for the 5-ΗΤ2A receptor, the invention may find application in numerous forms of therapy, such as against depression or drug addiction.
(FR) La présente invention concerne un procédé amélioré de production de diéthylamide d'acide lysergique (LSD) à des fins de GMP. En outre, la présente invention concerne de nouveaux dérivés du LSD de formule (I) ainsi que leur synthèse et purification. Du fait de l'affinité des substances présentées pour le récepteur 5-ΗΤ2A, l'invention peut trouver une application dans de nombreuses formes de thérapie, par exemple contre la dépression ou la toxicomanie.
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