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1. WO2022008578 - TARGETED DEPLETION OF NON-TARGET LIBRARY MOLECULES USING POISON PRIMERS DURING TARGET CAPTURE OF NEXT-GENERATION SEQUENCING LIBRARIES

Publication Number WO/2022/008578
Publication Date 13.01.2022
International Application No. PCT/EP2021/068782
International Filing Date 07.07.2021
IPC
C12Q 1/6848 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6848characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, WS, ZA, ZM, ZW)
  • ROCHE DIAGNOSTICS GMBH [DE]/[DE] (DE)
  • ROCHE SEQUENCING SOLUTIONS, INC. [US]/[US] (US)
  • KAPA BIOSYSTEMS, INC. [US]/[US]
Inventors
  • DANNEBAUM, Richard
  • GODWIN, Brian Christopher
  • PENKLER, David L.
  • SLABBERT, Etienne
  • VAN DER MERWE, Ruben
Agents
  • HILDEBRANDT, Martin
Priority Data
63/049,25508.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TARGETED DEPLETION OF NON-TARGET LIBRARY MOLECULES USING POISON PRIMERS DURING TARGET CAPTURE OF NEXT-GENERATION SEQUENCING LIBRARIES
(FR) DÉPLÉTION CIBLÉE DE MOLÉCULES DE BIBLIOTHÈQUE NON CIBLES À L'AIDE D'AMORCES POISON PENDANT LA CAPTURE CIBLE DE BIBLIOTHÈQUES DE SÉQUENÇAGE DE NOUVELLE GÉNÉRATION
Abstract
(EN) The present disclosure is directed to compositions, kits, and methods of target enrichment by unidirectional primer extension, whereby the compositions, kits, and methods utilize both poison primers and target capture primers.
(FR) La présente divulgation concerne des compositions, des kits et des procédés d'enrichissement de cible par extension d'amorce unidirectionnelle, les compositions, les kits et les procédés utilisant à la fois des amorces Poison et des amorces Capture cibles.
Latest bibliographic data on file with the International Bureau