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1. WO2022008527 - POLYMERIC MICELLES COMPRISING GLUCURONIDE-PRODRUGS

Publication Number WO/2022/008527
Publication Date 13.01.2022
International Application No. PCT/EP2021/068694
International Filing Date 06.07.2021
IPC
C07H 15/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
C07H 15/203 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
C07H 15/252 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
24Condensed ring systems having three or more rings
252Naphthacene radicals, e.g. daunomycins, adriamycins
A61P 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 47/54 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
Applicants
  • RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN [DE]/[DE]
Inventors
  • SHI, Yang
  • LAMMERS, Twan
  • METSELAAR, Josbert Maarten
Agents
  • WITMANS, H.a.
Priority Data
10 2020 208 448.306.07.2020DE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POLYMERIC MICELLES COMPRISING GLUCURONIDE-PRODRUGS
(FR) MICELLES POLYMÈRES COMPRENANT DES PROMÉDICAMENTS À BASE DE GLUCURONIDE
Abstract
(EN) The invention relates to a polymeric micelle comprising a block copolymer comprising a polyethylene glycol (PEG) hydrophilic block and a hydrophobic block, and a compound according to formula (I) or formula (III) encapsulated within said polymeric micelle and to uses thereof.
(FR) L'invention concerne une micelle polymère comprenant un copolymère séquencé comportant un polyéthylène glycol (PEG) hydrophile et un bloc hydrophobe, ainsi qu'un composé selon la formule (I) ou la formule (III) encapsulé dans ladite micelle polymère et leurs utilisations.
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