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1. WO2022008419 - ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES

Publication Number WO/2022/008419
Publication Date 13.01.2022
International Application No. PCT/EP2021/068472
International Filing Date 05.07.2021
IPC
A61K 47/68 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 475/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
475Heterocyclic compounds containing pteridine ring systems
06with a nitrogen atom directly attached in position 4
08with a nitrogen atom directly attached in position 2
Applicants
  • BYONDIS B.V. [NL]/[NL]
Inventors
  • ELGERSMA, Ronald Christiaan
  • HUIJBREGTS, Tijl
  • WAALBOER, Dennis Christian Johannes
  • JOOSTEN, Johannes Albertus Frederikus
Agents
  • VAN DER STERREN-MOL, Josephine
Priority Data
20184177.206.07.2020EP
21176011.126.05.2021EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES
(FR) MÉDICAMENTS LIEURS D'ANTIFOLATE ET CONJUGUÉS ANTICORPS-MÉDICAMENT
Abstract
(EN) The present invention relates to novel antifolate linker-drugs, conjugates comprising such antifolate linker-drugs, and the use thereof in the treatment of diseases, such as cancer, autoimmune and infectious diseases, optionally in combination with other therapeutic agents.
(FR) La présente invention concerne de nouveaux médicaments lieurs d'antifolate, des conjugués comprenant ces médicaments lieirs d'antifolate, et leur utilisation dans le traitement de maladies, telles qu'un cancer, des maladies auto-immunes et infectieuses, éventuellement en combinaison avec d'autres agents thérapeutiques.
Latest bibliographic data on file with the International Bureau