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1. WO2022007982 - PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Publication Number WO/2022/007982
Publication Date 13.01.2022
International Application No. PCT/CN2021/117404
International Filing Date 09.09.2021
IPC
A61K 31/445 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61K 31/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
51Thiamines, e.g. vitamin B1
A61K 9/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 9/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • 上海日馨医药科技股份有限公司 SHANGHAI RAISING PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 钟春玖 ZHONG, Chunjiu
  • 张寰 ZHANG, Huan
Agents
  • 北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.
Priority Data
202010662333.610.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
(FR) COMPOSITION PHARMACEUTIQUE ET SON APPLICATION
(ZH) 一种药物组合物及其应用
Abstract
(EN) A pharmaceutical composition containing benfotiamine or a pharmaceutically acceptable salt thereof; and donepezil or a pharmaceutically acceptable salt thereof. When combining administration of benfotiamine and donepezil hydrochloride, a better synergistic effect is achieved, the spatial learning memory capacity of an AD mouse can be improved relatively well, and the effect is better than the effect of benfotiamine or donepezil hydrochloride when administered alone, providing for excellent pharmaceutical activity in the treatment of Alzheimer's disease.
(FR) L'invention concerne une composition pharmaceutique contenant de la benfotiamine ou un sel pharmaceutiquement acceptable de celle-ci; et du donépézil ou un sel pharmaceutiquement acceptable de celui-ci. Des résultats expérimentaux ont démontré que lors de l'administration asociée de benfotiamine et de chlorhydrate de donépézil, un meilleur effet synergique est obtenu, la capacité de mémoire d'apprentissage spatial d'une souris AD peut être relativement bien améliorée, et l'effet est significativement meilleur que l'effet de la benfotiamine ou du chlorhydrate de donépézil lors d'une administration seule, la composition pharmaceutique de la présente invention s'avérant présenter une meilleure activité pharmaceutique dans le traitement de la maladie d'Alzheimer.
(ZH) 本发明公开了一种药物组合物,所述药物组合物包含苯磷硫胺或其药学上可接受的盐;和多奈哌齐或其药学上可接受的盐。实验结果表明,苯磷硫胺和盐酸多奈哌齐联合给药后,取得了较好的协同效果,可较好改善AD小鼠的空间学习记忆能力,且效果显著优于苯磷硫胺或盐酸多奈哌齐在单独用药时的效果,表明本发明药物组合物在治疗阿尔茨海默病方面有较好的药物活性。
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