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1. WO2022007965 - ANTI-IGE ENGINEERED ANTIBODY AND APPLICATION THEREOF

Publication Number WO/2022/007965
Publication Date 13.01.2022
International Application No. PCT/CN2021/105620
International Filing Date 09.07.2021
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
Applicants
  • 上海济煜医药科技有限公司 SHANGHAI JEMINCARE PHARM CO., LTD. [CN]/[CN]
  • 江西济民可信集团有限公司 JIANGXI JEMINCARE GROUP CO., LTD. [CN]/[CN]
Inventors
  • 邓俗俊 DENG, Sujun
  • 顾春银 GU, Chunyin
  • 刘小五 LIU, Xiaowu
  • 曹晓丹 CAO, Xiaodan
  • 刘培培 LIU, Peipei
  • 张建建 ZHANG, Jianjian
  • 潘忠宗 PAN, Zhongzong
  • 肖政 XIAO, Zheng
  • 王学萍 WANG, Xueping
  • 郭海兵 GUO, Haibing
Agents
  • 上海巅石知识产权代理事务所(普通合伙) SHANGHAI DIANSHI PARTNERS, P.C.
Priority Data
202010663029.310.07.2020CN
202110750959.701.07.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTI-IGE ENGINEERED ANTIBODY AND APPLICATION THEREOF
(FR) ANTICORPS ANTI-IGE MODIFIÉ ET SON APPLICATION
(ZH) 一种抗IgE的工程化抗体及其应用
Abstract
(EN) An antigen binding protein. Compared with the light and heavy chain variable region sequences of omalizumab, the antigen binding protein comprises an amino acid mutant. The antigen binding protein is an anti-IgE engineered antibody. Further involved are a pharmaceutical composition comprising the antigen binding protein, and a method thereof for relieving or treating a disease related to an abnormal IgE level.
(FR) L'invention concerne une protéine de liaison à l'antigène. Par comparaison avec les séquences de région variable de chaîne légère et lourde d'omalizumab, la protéine de liaison à l'antigène comprend un mutant d'acide aminé. La protéine de liaison à l'antigène est un anticorps anti-IgE modifié. L'invention concerne en outre une composition pharmaceutique comprenant la protéine de liaison à l'antigène, et un procédé associé pour atténuer ou traiter une maladie liée à un niveau d'IgE anormal.
(ZH) 一种抗原结合蛋白,其与奥马珠单抗的轻重链可变区序列相比,包含氨基酸突变,该抗原结合蛋白为抗IgE的工程化抗体。还涉及包含所述抗原结合蛋白的药物组合物,以及其用于缓解或治疗与异常IgE水平相关的疾病的方法。
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