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1. WO2022007796 - IMMUNE CELL CO-EXPRESSING IL-21 AND HRCD16 CHIMERIC RECEPTOR, AND APPLICATION THEREOF

Publication Number WO/2022/007796
Publication Date 13.01.2022
International Application No. PCT/CN2021/104765
International Filing Date 06.07.2021
IPC
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
C07K 14/735 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
735Fc receptors
C07K 16/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
CPC
A61K 2039/5156
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5156expressing foreign proteins
A61K 2039/5158
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5158Antigen-pulsed cells, e.g. T-cells
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/00114
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001136Cytokines
00114Interleukins [IL]
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
Applicants
  • 上海鑫湾生物科技有限公司 SHANGHAI SINOBAY BIOTECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 徐建青 XU, Jianqing
  • 张晓燕 ZHANG, Xiaoyan
  • 廖启彬 LIAO, Qibin
  • 丁相卿 DING, Xiangqing
Agents
  • 北京泛华伟业知识产权代理有限公司 PANAWELL & PARTNERS, LLC
Priority Data
202010645503.X06.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IMMUNE CELL CO-EXPRESSING IL-21 AND HRCD16 CHIMERIC RECEPTOR, AND APPLICATION THEREOF
(FR) CELLULE IMMUNITAIRE CO-EXPRIMANT LE RÉCEPTEUR CHIMÉRIQUE IL-21 ET HRCD16, ET SON APPLICATION
(ZH) 共表达IL-21和hrCD16嵌合受体的免疫细胞及其应用
Abstract
(EN) An immune cell co-expressing IL-21 and a hrCD16 chimeric receptor. The hrCD16 chimeric receptor comprises: (1) an extracellular recognition domain; (2) an extracellular spacer region; (3) a transmembrane region; and (4) an intracellular signaling domain. Optionally, the chimeric receptor further comprises: (5) one or more costimulatory signaling domains; and/or (6) one or more cytokine receptor signaling domains. A combination comprising the immune cell and a tumor antigen-targeting antibody or a virus antigen-targeting antibody is provided. The provided immune cell co-expresses IL-21, can effectively kill different types of tumor cells/virus-infected cells, can also be used as a collateral immune cell, and can initiate an endogenous anti-tumor/virus immune response.
(FR) Cellule immunitaire co-exprimant le récepteur chimérique IL-21 et hrCD16. Le récepteur chimérique hrCD16 comprend les éléments suivants : (1) Un domaine de reconnaissance extracellulaire ; (2) une région d'espaceur extracellulaire ; (3) une région transmembranaire ; et (4) un domaine de signalisation intracellulaire. Facultativement, le récepteur chimérique comprend en outre les éléments suivants : (5) Un ou plusieurs domaines de signalisation costimulants ; et/ou (6) un ou plusieurs domaines de signalisation de récepteur de cytokine. L'invention concerne également une combinaison comprenant la cellule immunitaire et un anticorps ciblant un antigène tumoral ou un anticorps ciblant un antigène viral. La cellule immunitaire fournie co-exprime l'IL-21, peut tuer efficacement différents types de cellules tumorales/cellules infectées par un virus, peut également être utilisée comme cellule immunitaire collatérale, et peut initier une réponse immunitaire endogène anti-tumorale/virale.
(ZH) 一种共表达IL-21和hrCD16嵌合受体的免疫细胞,其中,所述hrCD16嵌合受体包含:(1)胞外识别域;(2)胞外间隔区;(3)跨膜区;(4)胞内信号传导结构域;任选地,所述嵌合受体还包含(5)一个或多个共刺激信号传导结构域;和/或(6)一个或多个细胞因子受体信号传导结构域。提供了包含所述免疫细胞和肿瘤抗原靶向抗体或病毒抗原靶向抗体的组合;所提供的免疫细胞共表达IL-21,既可以高效杀伤不同类型的肿瘤细胞/病毒感染细胞,又可以作用于旁系免疫细胞,同时启动内源性抗肿瘤/病毒免疫应答。
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