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1. WO2022007769 - PYRROLIDINE AMIDE DERIVATIVE SALT AND USE THEREOF

Publication Number WO/2022/007769
Publication Date 13.01.2022
International Application No. PCT/CN2021/104625
International Filing Date 06.07.2021
IPC
C07D 207/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/401 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • 东莞市东阳光新药研发有限公司 DONGGUAN HEC NEW DRUG R&D CO., LTD. [CN]/[CN]
  • 广东东阳光药业有限公司 SUNSHINE LAKE PHARMA CO., LTD. [CN]/[CN]
Inventors
  • 金传飞 JIN, Chuanfei
  • 陈康智 CHEN, Kangzhi
  • 张英俊 ZHANG, Yingjun
Priority Data
202010643540.707.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PYRROLIDINE AMIDE DERIVATIVE SALT AND USE THEREOF
(FR) SEL DE DÉRIVÉ DE PYRROLIDINE AMIDE SON UTILISATION
(ZH) 吡咯烷酰胺衍生物的盐及其用途
Abstract
(EN) The present invention relates to a pyrrolidine amide derivative salt and the use thereof. The present invention further relates to a pharmaceutical composition containing the salt, and the use of the salt or the pharmaceutical composition containing the salt in the preparation of a drug for preventing, treating or alleviating diseases adjusted by means of MAO-B, wherein the diseases include neurodegenerative diseases, in particular Parkinson's disease.
(FR) La présente invention concerne un sel de dérivé de pyrrolidine amide son utilisation. La présente invention concerne en outre une composition pharmaceutique contenant le sel, et l'utilisation du sel ou de la composition pharmaceutique contenant le sel dans la préparation d'un médicament pour prévenir, traiter ou soulager des maladies régulées au moyen de MAO-B, les maladies comprenant des maladies neurodégénératives, en particulier la maladie de Parkinson.
(ZH) 涉及吡咯烷酰胺衍生物的盐及其用途。还涉及包含所述盐的药物组合物,以及所述盐或所述盐的药物组合物在制备用于预防、治疗或减轻通过MAO-B进行调节的疾病包括神经退行性疾病,特别是帕金森病的药物中的用途。
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