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1. WO2022007765 - PENTACYCLIC TRITERPENOID GLYCOSIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2022/007765
Publication Date 13.01.2022
International Application No. PCT/CN2021/104599
International Filing Date 05.07.2021
IPC
C07J 63/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
63Steroids in which the cyclopentahydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
A61K 31/58 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A61P 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 3/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 1/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
Applicants
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
Inventors
  • 柳红 LIU, Hong
  • 王江 WANG, Jiang
  • 刘怡楚 LIU, Yichu
  • 于常跃 YU, Changyue
  • 王一冰 WANG, Yibing
  • 蒋华良 JIANG, Hualiang
  • 陈凯先 CHEN, Kaixian
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
202010647960.207.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PENTACYCLIC TRITERPENOID GLYCOSIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSÉ GLYCOSIDE TRITERPÉNOÏDE PENTACYCLIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一类五环三萜类碳苷化合物及其制备方法和用途
Abstract
(EN) The present invention provides a pentacyclic triterpenoid glycoside compound, and a preparation method therefor and a use thereof. Specifically, the present invention provides a compound as shown in formula I. The definition of each group is described in the description. The compound can be used for preparing a medicament for treating metabolic diseases such as diabetes and viral diseases caused by influenza virus, coronavirus and the like.
(FR) La présente invention concerne un composé glycoside triterpénoïde pentacyclique, ainsi que son procédé de préparation et son utilisation. De façon spécifique, la présente invention concerne un composé tel que représenté dans la formule I. La définition de chaque groupe est décrite dans la description. Le composé peut être utilisé pour préparer un médicament destiné à traiter des maladies métaboliques telles que le diabète et des maladies virales provoquées par le virus de la grippe, le coronavirus et similaires.
(ZH) 本发明提供了一类五环三萜碳苷类化合物及其制备方法和用途,具体地,本发明提供了一种如式I所示的化合物,其中,各基团的定义如说明书中所述。所述的化合物可以用于制备治疗糖尿病等代谢类疾病和流感病毒、冠状病毒等引起的病毒性疾病。
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