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1. WO2022007758 - BRIVARACETAM PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2022/007758
Publication Date 13.01.2022
International Application No. PCT/CN2021/104586
International Filing Date 05.07.2021
IPC
A61K 9/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
A61K 9/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
A61K 31/4015 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4015having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61P 25/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • 上海博志研新药物技术有限公司 SHANGHAI BOCIMED PHARMACEUTICAL CO., LTD. [CN]/[CN]
  • 上海博志研新药物研究有限公司 SHANGHAI BOCIMED PHARMACEUTICAL RESEARCH CO., LTD. [CN]/[CN]
Inventors
  • 郭桢 GUO, Zhen
  • 陈丽娜 CHEN, Lina
  • 温益峰 WEN, Yifeng
  • 王婷婷 WANG, Tingting
  • 应述欢 YING, Shuhuan
Agents
  • 北京知元同创知识产权代理事务所(普通合伙) BEIJING ORIGINTELLIGENCE IP LAW FIRM
Priority Data
202010655757.X09.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BRIVARACETAM PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) COMPOSITION PHARMACEUTIQUE DE BRIVARACÉTAM, SON PROCÉDÉ DE PRÉPARATION ET APPLICATION ASSOCIÉE
(ZH) 一种布瓦西坦药物组合物、其制备方法及应用
Abstract
(EN) Provided is a brivaracetam pharmaceutical composition, a preparation method therefor and an application thereof. The pharmaceutical composition comprises a pharmaceutical active ingredient, a matrix-forming agent, and a swelling agent. The brivaracetam pharmaceutical composition has a sustained-release effect. Compared with ordinary gel matrix sustained-release preparations, the release curve thereof is smoother, thus achieving the purpose of reducing the drug release rate, controlling the effective dose of the drug within the body, enabling the blood drug concentration to be more stable, reducing toxic side effects, and reducing the number of administrations per day.
(FR) La présente invention concerne une composition de brivaracétam, son procédé de préparation et une application associée. La composition pharmaceutique comprend un principe actif pharmaceutique, un agent de formation de matrice et un agent gonflant. La composition pharmaceutique de brivaracétam présente un effet de libération prolongée. Par comparaison avec des préparations à libération prolongée à matrice de gel ordinaire, sa courbe de libération est plus lisse, ce qui permet de réduire la vitesse de libération du médicament, de réguler la dose efficace du médicament à l'intérieur du corps, de permettre à la concentration sanguine du médicament d'être plus stable, de réduire les effets secondaires toxiques et le nombre d'administrations quotidiennes.
(ZH) 提供了一种布瓦西坦药物组合物、其制备方法及应用。所述药物组合物包括药物活性成分、基质形成剂和溶胀剂。所述布瓦西坦药物组合物具有缓释作用,与普通凝胶骨架缓释制剂相比释放曲线更平缓,达到了降低药物释放速率、控制药物在体内的有效剂量、血药浓度更加平稳、降低毒副作用、降低每日给药次数的目的。
Related patent documents
EP2021787288This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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