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1. WO2022007713 - USE OF TAUROLIDINE AGAINST VIRUS

Publication Number WO/2022/007713
Publication Date 13.01.2022
International Application No. PCT/CN2021/104197
International Filing Date 02.07.2021
Chapter 2 Demand Filed 29.01.2022
IPC
A61K 31/549 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
549having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
CPC
A61K 31/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
549having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • 军事科学院军事医学研究院军事兽医研究所 ACADEMY OF MILITARY SCIENCES PLA CHINA ACADEMY OF MILITARY MEDICAL SCIENCES INSTITUTE OF MILITARY VETERINARY MEDICINE [CN]/[CN]
  • 长春迈灵生物工程有限公司 CHANGCHUN MAILING BIOLOGICAL ENGINEERING CO., LTD. [CN]/[CN]
Inventors
  • 高玉伟 GAO, Yuwei
  • 李元果 LI, Yuanguo
  • 吕朝相 LYU, Chaoxiang
  • 苏忠 SU, Zhong
  • 李松 LI, Song
  • 王铁成 WANG, Tiecheng
  • 钟武 ZHONG, Wu
  • 向海洋 XIANG, Haiyang
  • 周彤 ZHOU, Tong
  • 孙伟洋 SUN, Weiyang
  • 王雪峰 WANG, Xuefeng
  • 周博 ZHOU, Bo
  • 李恩涛 LI, Entao
  • 冯娜 FENG, Na
  • 赵永坤 ZHAO, Yongkun
  • 杨松涛 YANG, Songtao
  • 夏咸柱 XIA, Xianzhu
Agents
  • 中国贸促会专利商标事务所有限公司 CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
202010638926.906.07.2020CN
202010639186.006.07.2020CN
202010994928.121.09.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) USE OF TAUROLIDINE AGAINST VIRUS
(FR) UTILISATION DE LA TAUROLIDINE CONTRE UN VIRUS
(ZH) 牛磺罗定在抗病毒中的应用
Abstract
(EN) Provided in the present application is the use of taurolidine against a virus. Specifically provided in the present application are the use of taurolidine or a derivative, a prodrug, a solvate or a pharmaceutically acceptable salt thereof, or a composition containing taurolidine or a derivative, a prodrug, a solvate or a pharmaceutically acceptable salt thereof in the preparation of an antiviral drug. Research results show that taurolidine can significantly inhibit influenza viruses and coronaviruses at cell levels. In addition, in vivo experiments confirm that taurolidine has a significant protection effect on the lungs, and can prolong the survival time of mice infected with influenza viruses or SARS-CoV-2 viruses. It is indicated that taurolidine can be used for the prevention and treatment of pulmonary diseases caused by influenza viruses or coronaviruses. The research results of the present application broaden the efficacy range of taurolidine, and provide a research foundation and open up a new direction for the research and development of a drug for preventing or treating pulmonary infections caused by viruses.
(FR) La présente demande concerne l'utilisation de la taurolidine contre un virus. Plus particulièrement, la présente demande concerne l'utilisation de la taurolidine ou d'un dérivé, d'un promédicament, d'un solvate ou d'un sel pharmaceutiquement acceptable de celle-ci, ou d'une composition contenant la taurolidine ou un dérivé, un promédicament, un solvate ou un sel pharmaceutiquement acceptable de celle-ci dans la préparation d'un médicament antiviral. Des résultats de recherche montrent que la taurolidine peut inhiber significativement les virus de la grippe et les coronavirus à des niveaux cellulaires. De plus, des expériences in vivo confirment que la taurolidine présente un effet de protection significatif sur les poumons, et peut prolonger la durée de survie de souris infectées par des virus de la grippe ou des virus SARS-CoV-2. Il est indiqué que la taurolidine peut être utilisée pour la prévention et le traitement de maladies pulmonaires provoquées par des virus de la grippe ou des coronavirus. Les résultats de recherche de la présente demande permettent d'élargir la plage d'efficacité de la taurolidine, et fournissent une base de recherche et ouvrent une nouvelle voie pour la recherche et le développement d'un médicament pour la prévention ou le traitement d'infections pulmonaires provoquées par des virus.
(ZH) 本申请提供了牛磺罗定在抗病毒中的应用。具体地,本申请提供牛磺罗定或其衍生物、前药、溶剂合物或药学上可接受的盐、或含有牛磺罗定或其衍生物、前药、溶剂合物或药学上可接受的盐的组合物在制备抗病毒药物中的用途。研究结果显示,牛磺罗定在细胞水平上能够显著抑制流感病毒和冠状病毒。另外,体内实验证实牛磺罗定对肺脏具有显著的保护作用,能延长流感病毒或SARS-CoV-2病毒感染小鼠的生存时间。表明牛磺罗定可用于流感病毒或冠状病毒引起的肺部疾病的预防和治疗。本申请的研究结果拓展了牛磺罗定的功效范围,为预防或治疗由病毒引起肺部感染药物的研发提供了研究基础和开辟了新方向。
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