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1. WO2022007543 - ANTI-FGL1 ANTIBODY AND USE THEREOF

Publication Number WO/2022/007543
Publication Date 13.01.2022
International Application No. PCT/CN2021/097569
International Filing Date 01.06.2021
IPC
C07K 16/36 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
36against blood coagulation factors
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
Applicants
  • 盛禾(中国)生物制药有限公司 SHENGHE (CHINA) BIOPHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 周冲 ZHOU, Chong
  • 姜晓玲 JIANG, Xiaoling
  • 王艺臻 WANG, Yizhen
  • 黄真真 HUANG, Zhenzhen
  • 吴崇兵 WU, Chongbing
Priority Data
202010655411.X09.07.2020CN
202110596951.X31.05.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTI-FGL1 ANTIBODY AND USE THEREOF
(FR) ANTICORPS ANTI-FGL1 ET SON UTILISATION
(ZH) 一种抗FGL1抗体及其应用
Abstract
(EN) Disclosed are an anti-FGL1 antibody or an antigen-binding fragment thereof, and uses and pharmaceutical compositions thereof. The anti-FGL1 antibody of the present invention can bind to FGL1 specifically, block the binding of FGL1 to LAG-3, reverse the inhibitory effect of FGL1 on T cells, and activate T cells to secrete cytokines.
(FR) L'invention concerne un anticorps anti-FGL1 ou un fragment de liaison à l'antigène de celui-ci, et des utilisations et des compositions pharmaceutiques correspondantes. L'anticorps anti-FGL1 de la présente invention peut se lier spécifiquement à FGL1, bloquer la liaison de FGL1 à LAG-3, inverser l'effet inhibiteur de FGL1 sur les lymphocytes T et activer les lymphocytes T pour provoquer la sécrétion de cytokines.
(ZH) 本发明公开了一种抗FGL1抗体或其抗原结合片段及其用途以及药物组合物。本发明提供的抗FGL1抗体能够特异性地与FGL1结合,阻断FGL1与LAG-3的结合,逆转FGL1对T细胞的抑制作用,激活T细胞分泌细胞因子。
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