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1. WO2022007502 - MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING SHP2

Publication Number WO/2022/007502
Publication Date 13.01.2022
International Application No. PCT/CN2021/094139
International Filing Date 17.05.2021
IPC
C07D 211/62 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
62attached in position 4
C07D 491/107 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
107with only one oxygen atom as ring hetero atom in the oxygen-containing ring
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 211/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
26with hydrocarbon radicals, substituted by nitrogen atoms
C07D 211/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 213/127 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
127Preparation from compounds containing pyridine rings
Applicants
  • NOVARTIS AG [CH]/[CH]
  • FEI, Zhongbo [CN]/[CN] (US)
  • LI, Wei [CN]/[CN] (US)
  • YU, Huangchao [CN]/[CN] (US)
  • JIA, Huanqing [CN]/[CN] (US)
  • WANG, Jianhua [CN]/[CN] (US)
Inventors
  • FEI, Zhongbo
  • LI, Wei
  • YU, Huangchao
  • JIA, Huanqing
  • WANG, Jianhua
Agents
  • ZHONGZI LAW OFFICE
Priority Data
PCT/CN2020/10088208.07.2020CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING SHP2
(FR) FABRICATION DE COMPOSÉS ET DE COMPOSITIONS POUR INHIBER SHP2
Abstract
(EN) Provided herein is a method for the manufacture of a compound of Formula (I) or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula (II) with a compound of the formula (III) according to the following reaction scheme: wherein LG, A, n, m and p are as defined herein, said manufacture including the manufacture and use of a compound of the formula (VI): wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.
(FR) L'invention concerne un procédé de fabrication d'un composé de formule (I) ou un sel pharmaceutiquement acceptable, un co-cristal d'acide, un hydrate ou un autre solvate de celui-ci, ledit procédé comprenant la réaction d'un composé de formule (II) avec un composé de formule (III) selon le schéma réactionnel suivant : LG, A, n, m et p étant tels que définis dans la description, ladite fabrication comprenant la production et l'utilisation d'un composé de formule (VI) : dans laquelle R1 représente un groupe protecteur amino secondaire et R5 représente alkyle non substitué ou substitué, cycloalkyle non substitué ou substitué ou aryle substitué ou non substitué.
Latest bibliographic data on file with the International Bureau