Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022007462 - IMMUNOMODULATOR

Publication Number WO/2022/007462
Publication Date 13.01.2022
International Application No. PCT/CN2021/087553
International Filing Date 15.04.2021
IPC
C07D 403/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 487/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
A61K 31/4184 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07D 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applicants
  • 成都先导药物开发股份有限公司 HITGEN INC. [CN]/[CN]
Inventors
  • 李进 LI, Jin
  • 张登友 ZHANG, Dengyou
  • 白晓光 BAI, Xiaoguang
  • 龚义 GONG, Yi
  • 周贤思 ZHOU, Xiansi
  • 刘立川 LIU, Lichuan
  • 李清然 LI, Qingran
  • 陈欣 CHEN, Xin
  • 兰燕 LAN, Yan
Agents
  • 深圳市韦恩肯知识产权代理有限公司 WAYNE INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
202010610045.604.07.2020CN
202010661625.814.07.2020CN
202110172530.409.02.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IMMUNOMODULATOR
(FR) IMMUNOMODULATEUR
(ZH) 一种免疫调节剂
Abstract
(EN) Disclosed in the present invention is an immunomodulator, specifically relating to a compound that inhibits IL-17A and the use thereof as an immunomodulator in the preparation of a drug. Disclosed in the present invention is the use of a compound as represented by formula I or a stereoisomer thereof in the preparation of a drug for inhibiting IL-17A, wherein same provides a new option for clinically screening and/or preparing a drug for treating diseases associated with IL-17A activity.
(FR) La présente invention concerne un immunomodulateur, en particulier un composé qui inhibe l'IL-17A et son utilisation en tant qu'immunomodulateur dans la préparation d'un médicament. La présente invention concerne l'utilisation d'un composé tel que représenté par la formule I ou d'un stéréoisomère de celui-ci dans la préparation d'un médicament pour inhiber l'IL-17A, ce qui fournit une nouvelle option pour le criblage clinique et/ou la préparation d'un médicament pour le traitement de maladies associées à l'activité de l'IL-17A.
(ZH) 本发明公开了一种免疫调节剂,具体涉及一类抑制IL-17A的化合物及其作为免疫调节剂在制备药物中的用途。本发明公开了式I所示的化合物、或其立体异构体在制备抑制IL-17A类药物中的用途,为临床上筛选和/或制备与IL-17A活性相关的疾病的药物提供了一种新的选择。
Latest bibliographic data on file with the International Bureau