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1. WO2022007420 - ANTI-VIRAL COMPOUNDS AND METHODS FOR SCREENING SAME AND TREATING VIRAL INFECTIONS

Publication Number WO/2022/007420
Publication Date 13.01.2022
International Application No. PCT/CN2021/077938
International Filing Date 25.02.2021
IPC
C07D 209/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
10with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
16Tryptamines
A61K 31/4045 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61P 31/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
Applicants
  • HOU, Ming-Hung [CN]/[CN]
Inventors
  • HOU, Ming-Hung
Agents
  • LUNG TIN INTELLECTUAL PROPERTY AGENT LTD.
Priority Data
63/048,16905.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-VIRAL COMPOUNDS AND METHODS FOR SCREENING SAME AND TREATING VIRAL INFECTIONS
(FR) COMPOSÉS ANTIVIRAUX, LEURS PROCÉDÉS DE CRIBLAGE ET MÉTHODES DE TRAITEMENT D'INFECTIONS VIRALES
Abstract
(EN) Disclosed is a compound of formula (I), where R1 to R4 are as defined herein, and a method for treating a viral infection in a subject in need thereof by administering with the compound. Also provided is a method for screening a compound capable of inhibiting activities of a coronavirus in a host cell, including identifying a compound that modulates a non-native protein-protein interaction in coronaviral nucleocapsid (N) proteins.
(FR) L'invention concerne un composé de formule (I), dans laquelle R1 à R4 sont tels que définis dans la description, et une méthode de traitement d'une infection virale chez un sujet en ayant besoin par administration du composé. L'invention concerne également un procédé de criblage d'un composé capable d'inhiber les activités d'un coronavirus dans une cellule hôte, comprenant l'identification d'un composé qui module une interaction protéine-protéine non native dans des protéines de la nucléocapside (N) coronavirale.
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