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1. WO2022007304 - IGA ANTIBODY SPECIFICALLY RECOGNIZING RBD PROTEIN AND TESTING KIT

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Publication Number WO/2022/007304
Publication Date 13.01.2022
International Application No. PCT/CN2020/130496
International Filing Date 20.11.2020
IPC
C07K 16/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Applicants
  • 深圳市亚辉龙生物科技股份有限公司 SHENZHEN YHLO BIOTECH CO., LTD [CN]/[CN]
Inventors
  • 程方明 CHENG, Fangming
  • 林晓涛 LIN, Xiaotao
  • 党智笙 DANG, Zhisheng
  • 吴力强 WU, Liqiang
  • 钱纯亘 QIAN, Chungen
  • 胡鹍辉 HU, Kunhui
Agents
  • 广州华进联合专利商标代理有限公司 ADVANCE CHINA IP LAW OFFICE
Priority Data
202010639269.X06.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IGA ANTIBODY SPECIFICALLY RECOGNIZING RBD PROTEIN AND TESTING KIT
(FR) ANTICORPS D'IGA RECONNAISSANT SPÉCIFIQUEMENT UNE PROTÉINE RBD ET KIT DE TEST
(ZH) 能够特异性识别RBD蛋白的IgA抗体以及试剂盒
Abstract
(EN) The present invention relates to the technical field of virus testing. Provided is an IgA antibody capable of specifically recognizing an RBD protein. Said antibody is applied as a calibrator of the IgA antibody of the RBD protein of SARS-CoV-2. Also provided is a testing kit including said antibody. The testing kit achieves the automatic, high-throughput, and rapid testing of IgA antibodies of SARS-CoV-2.
(FR) La présente invention concerne le domaine technique du test de virus. L'invention concerne un anticorps d'IgA capable de reconnaître spécifiquement une protéine RBD. Ledit anticorps est appliqué en tant qu'étalon de l'anticorps IgA de la protéine RBD du SARS-CoV-2. L'invention concerne également un kit de test comprenant ledit anticorps. Le kit de test permet un test automatique, à haut rendement et rapide d'anticorps IgA du SARS-CoV-2.
(ZH) 本发明属于病毒检测技术领域，提供了一种能够特异性识别RBD蛋白的IgA抗体，该抗体可以作为SARS-CoV-2的RBD蛋白的IgA抗体的校准品应用。本发明还提供了包含该抗体的试剂盒，该试剂盒能够实现对新型冠状病毒肺炎IgA抗体的自动化、高通量、快速检测。
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