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1. WO2022007153 - TUMOR-TARGETING NANODRUG SIMULTANEOUSLY ENCLOSING PHOTOSENSITIZER AND PROTEIN, AND USE THEREOF

Publication Number WO/2022/007153
Publication Date 13.01.2022
International Application No. PCT/CN2020/112583
International Filing Date 31.08.2020
IPC
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 47/42 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 47/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 福建医科大学孟超肝胆医院(福州市传染病医院) MENGCHAO HEPATOBILIARY HOSPITAL OF FUJIAN MEDICAL UNIVERSITY (FUZHOU INFECTIOUS DISEASE HOSPITAL) [CN]/[CN]
Inventors
  • 张晓龙 ZHANG, Xiaolong
  • 曾永毅 ZENG, Yongyi
  • 刘小龙 LIU, Xiaolong
  • 丁磊 DING, Lei
Agents
  • 福州元创专利商标代理有限公司 FUZHOU YUANCHUANG PATENT AND TRADEMARK AGENT LTD.
Priority Data
202010653123.008.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) TUMOR-TARGETING NANODRUG SIMULTANEOUSLY ENCLOSING PHOTOSENSITIZER AND PROTEIN, AND USE THEREOF
(FR) NANOMÉDICAMENT CIBLANT UNE TUMEUR RENFERMANT SIMULTANÉMENT UN PHOTOSENSIBILISATEUR ET UNE PROTÉINE, ET SON UTILISATION
(ZH) 一种同时包载光敏剂和蛋白质的肿瘤靶向纳米药物及其应用
Abstract
(EN) A tumor-targeting nanodrug simultaneously enclosing a photosensitizer and a protein and the use thereof in the preparation of anti-tumor drugs. The tumor-targeting nanodrug is prepared by means of using a metal organic framework to enclose a hydrophobic photosensitizer and a protein drug, and then modifying same with a modifier. The tumor-targeting nanodrug has the characteristics of active targeting of tumor cells and drug release in response to a tumor microenvironment, and the synergistic treatment of photodynamic therapy and protein therapy along with fluorescence imaging can be realized, thereby achieving good diagnosis and treatment effects.
(FR) L'invention concerne un nanomédicament ciblant une tumeur renfermant simultanément un photosensibilisateur et une protéine et son utilisation dans la préparation de médicaments antitumoraux. Le nanomédicament ciblant une tumeur est préparé au moyen d'une structure organométallique pour enfermer un photosensibilisateur hydrophobe et un médicament protéique, puis par sa modification avec un modificateur. Le nanomédicament ciblant une tumeur a les caractéristiques de ciblage actif de cellules tumorales et de libération de médicament en réponse à un microenvironnement tumoral, et le traitement synergique de la thérapie photodynamique et de la protéinothérapie conjointement avec une imagerie par fluorescence peut être réalisé, ce qui permet d'obtenir de bons effets de diagnostic et de traitement.
(ZH) 一种同时包载光敏剂和蛋白质的肿瘤靶向纳米药物及其在制备抗肿瘤药物中的应用,该肿瘤靶向纳米药物是利用金属有机框架包载疏水性光敏剂和蛋白质药物,并采用改性剂进行修饰而构成。所述肿瘤靶向纳米药物具有肿瘤细胞主动靶向及肿瘤微环境响应释放药物的特性,并能在荧光成像的同时实现光动力治疗和蛋白质治疗的协同治疗,从而达到良好的诊断与治疗效果。
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