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1. WO2022006745 - GUIDE RNA FOR HSV-1 GENE EDITING AND METHOD THEREOF

Publication Number WO/2022/006745
Publication Date 13.01.2022
International Application No. PCT/CN2020/100684
International Filing Date 07.07.2020
IPC
C12N 15/113 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/90 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
A61P 31/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
22for herpes viruses
Applicants
  • ORIENGENE BIOTECHNOLOGY LTD [CN]/[CN]
Inventors
  • LI, Xiaoming
  • SHU, Xiao
  • JIA, Ru
  • WANG, Ning
Agents
  • 北京市金杜律师事务所 KING & WOOD MALLESONS
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GUIDE RNA FOR HSV-1 GENE EDITING AND METHOD THEREOF
(FR) ARN GUIDE POUR L'ÉDITION DU GÈNE HSV-1 ET SON PROCÉDÉ
Abstract
(EN) Provided is a guide RNA (gRNA) comprising a guide sequence capable of targeting a Cas9 protein to a target sequence in an ICP6 gene of type 1-herpes simplex virus (HSV-1) to provide a specific cleavage event, wherein the target sequence comprises a GATC insertion as compared to a wild-type HSV-1. Also provided is a HSV-1 gene-editing system and a gene-editing method for generating a desired recombinant HSV-1 by using said gRNA.
(FR) La présente invention concerne un ARN guide (ARNg) comprenant une séquence guide capable de cibler une protéine Cas9 sur une séquence cible dans un gène ICP6 du virus de l'herpès simplex de type 1 (HSV-1) pour fournir un événement de clivage spécifique, la séquence cible comprenant une insertion GATC par rapport à un HSV-1 de type sauvage. L'invention concerne également un système d'édition de gène HSV-1 et un procédé d'édition de gène pour générer un HSV-1 recombiné souhaité en utilisant ledit ARNg.
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