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1. WO2022006660 - GENETICALLY MODIFIED BOVINE HERPESVIRUS TYPE 1 (BHV-1) FOR USE TO TREAT CANCER

Publication Number WO/2022/006660
Publication Date 13.01.2022
International Application No. PCT/CA2021/050915
International Filing Date 06.07.2021
IPC
C12N 7/01 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
A61K 35/763 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61K 39/245 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/52 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
Applicants
  • MCMASTER UNIVERSITY [CA]/[CA]
Inventors
  • MOSSMAN, Karen
  • DAVOLA, Maria
  • COLLINS, Susan
  • CUDDINGTON, Breanne
Agents
  • TANDAN, Susan
Priority Data
63/050,26010.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GENETICALLY MODIFIED BOVINE HERPESVIRUS TYPE 1 (BHV-1) FOR USE TO TREAT CANCER
(FR) HERPÈSVIRUS BOVIN DE TYPE 1 (BHV-1) GÉNÉTIQUEMENT MODIFIÉ DESTINÉ À ÊTRE UTILISÉ POUR TRAITER LE CANCER
Abstract
(EN) A recombinant BHV-1 oncolytic virus is provided comprising a BHV-1 mutant with enhanced cancer selectivity and/or enhance immunostimulatory activity as compared to wildtype BHV-1. The BHV-1 mutant is genetically modified to express one or more immunomodulatory molecules that induce an anti-tumor immune response. A method of generating the recombinant BHV-1 oncolytic virus is also provided.
(FR) L'Invention concerne un virus oncolytique BHV-1 recombiné comprenant un mutant de BHV-1 ayant une sélectivité accrue pour le cancer et/ou une activité immunostimulante accrue par rapport au BHV-1 de type sauvage. Le mutant BHV-1 est génétiquement modifié pour exprimer une ou plusieurs molécules immunomodulatrices induisant une réponse immunitaire anti-tumorale. La présente invention concerne également un procédé de production du virus oncolytique BHV-1 recombiné.
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