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1. WO2022006638 - DERIVATIVES OF 2-OXO-N-(4-(PYRIMIDIN-4-YLOXY/THIO)PHENYL)-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE FOR USE AS PROTEIN KINASE INHIBITORS FOR THERAPY

Publication Number WO/2022/006638
Publication Date 13.01.2022
International Application No. PCT/AU2021/050737
International Filing Date 09.07.2021
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07K 14/705 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 9/99
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
99Enzyme inactivation by chemical treatment
C12Y 207/10001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
207Transferases transferring phosphorus-containing groups (2.7)
10Protein-tyrosine kinases (2.7.10)
10001Receptor protein-tyrosine kinase (2.7.10.1)
Applicants
  • AUCENTRA THERAPEUTICS PTY LTD [AU]/[AU]
Inventors
  • WANG, Shudong
  • GOH, Aik Wye
Agents
  • MADDERNS PATENT & TRADE MARK ATTORNEYS
Priority Data
202090239210.07.2020AU
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DERIVATIVES OF 2-OXO-N-(4-(PYRIMIDIN-4-YLOXY/THIO)PHENYL)-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE FOR USE AS PROTEIN KINASE INHIBITORS FOR THERAPY
(FR) DÉRIVÉS DE 2-OXO-N-(4-(PYRIMIDIN-4-YLOXY/THIO)PHÉNYL)-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE DESTINÉS À ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE PROTÉINE KINASE POUR UNE THÉRAPIE
Abstract
(EN) 2-oxo-N-(4-(pyrimidin-4-yloxy/thio)phenyl)-1,2-dihydropyridine-3-carboxamide derivatives are disclosed for use in the prevention and/or treatment of proliferative cell diseases and conditions including cancers. The compounds are considered to be capable of inhibiting cell proliferation and cause cancer cell apoptosis by inhibiting the activity of receptor tyrosine kinases (RTKs) such as TYRO3, AXL, MER and/or MET. The compounds have the general structure (I) shown below:
(FR) L'invention concerne des dérivés de 2-oxo-N-(4-(pyrimidin-4-yloxy/thio)phényl)-1,2-dihydropyridine-3-carboxamide destinés à être utilisés dans la prévention et/ou le traitement de maladies et d'états associés à des cellules prolifératives, comprenant des cancers. Les composés sont considérés comme étant en mesure d'inhiber la prolifération cellulaire et de provoquer l'apoptose des cellules cancéreuses par l'inhibition de l'activité des tyrosine kinases réceptrices (RTK) telles que TYRO3, AXL, MER et/ou MET. Ces composés présentent la structure générale I représentée ci-dessous :
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