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1. WO2022006505 - PERFUSION-ENABLED BIOREACTOR

Publication Number WO/2022/006505
Publication Date 06.01.2022
International Application No. PCT/US2021/040264
International Filing Date 02.07.2021
IPC
C12M 3/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
C12M 1/14 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
14with means providing thin layers or with multi-level trays
C12M 1/26 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
C12M 1/28 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
26Inoculator or sampler
28being part of container
C12M 3/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
02with means providing suspensions
Applicants
  • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION [US]/[US]
Inventors
  • SAWYER, Wallace Gregory
  • SMOLCHEK, Ryan A.
  • URUEÑA VARGAS, Juan Manuel
  • FAMIGLIETTI, Jack E.
  • NGUYEN, Duy T.
Agents
  • DAVY-JOW, Stéphanie
Priority Data
63/047,67302.07.2020US
63/161,70416.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PERFUSION-ENABLED BIOREACTOR
(FR) BIORÉACTEUR À PERFUSION
Abstract
(EN) Provided herein are injection molded perfusion-enabled bioreactors and systems including said bioreactors. The bioreactor can include a lid, a frame comprising an array of sample wells, a membrane adhered to a bottom of the frame beneath the array of sample wells, and a skirt adhered to a bottom of the frame, such that the membrane is located between the frame and the skirt. The skirt can include a plurality of channels corresponding to the sample wells. When the sample wells are filled with a 3D cell culture support matrix, a pressure above the 3D cell culture support matrix is atmospheric pressure and a pressure below the membrane is less than atmospheric, thereby perfusing a fluid along a vertical fluid flow path from the sample wells through the 3D cell culture support matrix, through the membrane, and along the channels to the reservoir.
(FR) La présente invention concerne des bioréacteurs à perfusion moulés par injection et des systèmes comprenant lesdits bioréacteurs. Le bioréacteur peut comprendre un couvercle, un cadre comprenant un réseau de puits d'échantillons, une membrane collée à un fond du cadre sous le réseau de puits d'échantillons, et une jupe collée à un fond du cadre, de sorte que la membrane est située entre le cadre et la jupe. La jupe peut comprendre une pluralité de canaux correspondant aux puits d'échantillons. Lorsque les puits d'échantillons sont remplis avec une matrice de support de culture cellulaire 3D, une pression au-dessus de la matrice de support de culture cellulaire 3D est la pression atmosphérique et une pression sous la membrane est inférieure à la pression atmosphérique, ce qui permet de perfuser un liquide le long d'un trajet vertical d'écoulement de liquide depuis les puits d'échantillons à travers la matrice de support de culture cellulaire 3D, à travers la membrane, et le long des canaux vers le réservoir.
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