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1. WO2022006492 - RECOMBINANT SIALIDASES WITH REDUCED PROTEASE SENSITIVITY, SIALIDASE FUSION PROTEINS, AND METHODS OF USING THE SAME

Publication Number WO/2022/006492
Publication Date 06.01.2022
International Application No. PCT/US2021/040240
International Filing Date 02.07.2021
IPC
C12N 9/24 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
24acting on glycosyl compounds (3.2)
A61K 38/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
47acting on glycosyl compounds (3.2), e.g. cellulases, lactases
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • PALLEON PHARMACEUTICALS INC. [US]/[US]
Inventors
  • PENG, Li
  • SHELKE, Sandip A.
  • CAO, Lizhi
Agents
  • GUSTAFSON, Megan A.
Priority Data
63/047,98903.07.2020US
63/134,41106.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) RECOMBINANT SIALIDASES WITH REDUCED PROTEASE SENSITIVITY, SIALIDASE FUSION PROTEINS, AND METHODS OF USING THE SAME
(FR) SIALIDASES RECOMBINANTES À SENSIBILITÉ À LA PROTÉASE RÉDUITE, PROTÉINES DE FUSION DE SIALIDASE ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN) The invention relates generally to recombinant sialidases (for example, recombinant sialidases having reduced protease sensitivity), recombinant fusion proteins, and antibody conjugates, and their use in the treatment of cancer.
(FR) L'invention concerne globalement des sialidases recombinantes (par exemple des sialidases recombinantes ayant une sensibilité à la protéase réduite), des protéines de fusion recombinantes et des conjugués d'anticorps, ainsi que leur utilisation dans le traitement du cancer.
Latest bibliographic data on file with the International Bureau