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1. WO2022006332 - GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS

Publication Number WO/2022/006332
Publication Date 06.01.2022
International Application No. PCT/US2021/039983
International Filing Date 30.06.2021
IPC
A61K 35/28 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 35/15 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
A61K 38/21 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
Applicants
  • CHAN ZUCKERBERG BIOHUB, INC. [US]/[US]
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • PAULK, Nicole K.
  • DERISI, Joseph L.
  • RALEIGH, David R.
Agents
  • LOCKYER, Jean M.
  • APPLE, Randolph T.
Priority Data
63/046,21130.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
(FR) THÉRAPIE GÉNIQUE POUR APPLICATIONS D'IMMUNO-ONCOLOGIE
Abstract
(EN) The invention provides compositions and methods for treatment of glioblastoma and other conditions. In particular, the invention provides a recombinant adeno-associated virus (AAV) vector comprising a transgene encoding one or more interferon polypeptides and a CAG promoter which directs the expression of the transgene. The compositions are particularly suitable for intratumoral administration in gene therapy applications.
(FR) L'invention concerne des compositions et des méthodes pour le traitement du glioblastome et d'autres pathologies. En particulier, l'invention concerne un vecteur du type virus adéno-associé (VAA) recombinant comprenant un transgène codant pour un ou plusieurs polypeptides d'interféron et un promoteur CAG qui dirige l'expression du transgène. Les compositions sont particulièrement appropriées pour une administration intratumorale dans des applications de thérapie génique.
Latest bibliographic data on file with the International Bureau