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1. WO2022006271 - NANOPARTICLES AND METHODS OF MANUFACTURE THEREOF

Publication Number WO/2022/006271
Publication Date 06.01.2022
International Application No. PCT/US2021/039889
International Filing Date 30.06.2021
IPC
A61K 31/337 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
A61K 31/454 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/473 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
473ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
Applicants
  • HILLSTREAM BIOPHARMA INC. [US]/[US]
Inventors
  • SINGH, Harpal
  • MILBY, Randy
  • TIWARI, Sachchidanand
  • MOHAMMAD, Anees
Agents
  • COUGHLIN, Sean M.
  • BRESE, Robin L.
  • BUCCI, Michael David
  • DAVIS, Chad E.
  • FLEMING, Paul
  • MANAS, Michael
  • NIHAN, Danielle
  • WANG, Gang
  • STEVENSON, Christian P.
  • WILKINS, Andrew Thomas
Priority Data
63/046,50830.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NANOPARTICLES AND METHODS OF MANUFACTURE THEREOF
(FR) NANOPARTICULES ET LEURS PROCÉDÉS DE FABRICATION
Abstract
(EN) Provided herein is a biodegradable polymeric nanoparticle formed of hybrid block copolymers comprising a di-block copolymer methoxy-poly(ethylene glycol)-poly(lactic acid) (m-PEG-PLA) and/or a penta-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PPG-PEG-PLA). Also provided herein are methods of preparing biodegradable polymeric nanoparticles.
(FR) La présente invention concerne une nanoparticule polymère biodégradable formée de copolymères séquencés hybrides comprenant un copolymère di-séquencé de méthoxy-poly(éthylène glycol)-poly(acide lactique) (m-PEG-PLA) et/ou un copolymère penta-séquencé de poly(acide lactique)-poly(éthylène glycol)-poly(propylène glycol)-poly(éthylène glycol)-poly(acide lactique) (PLA-PEG-PPG-PEG-PLA). L'invention concerne également des procédés de préparation de nanoparticules polymères biodégradables.
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