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1. WO2022006253 - METHODS AND COMPOSITIONS FOR ADMINISTERING RECOMBINANT VIRAL VECTORS

Publication Number WO/2022/006253
Publication Date 06.01.2022
International Application No. PCT/US2021/039860
International Filing Date 30.06.2021
IPC
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 31/573 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone
A61K 38/13 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
13Cyclosporins
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • UNIVERSITY OF IOWA RESEARCH FOUNDATION [US]/[US]
  • YUEN, Eric [US]/[US]
Inventors
  • YUEN, Eric
  • TANG, Yinghua
  • YANG, Ziying
  • ENGELHARDT, John F.
Agents
  • PERDOK, Monique M.
  • ARORA, Suneel, Reg. No. 42,267
  • BEEKMAN, Marvin L., Reg. No. 38,377
  • BIANCHI, Timothy E., Reg. No. 39,610
  • BLACK, David W., Reg. No. 42,331
  • LANG, Allen R., Reg. No. 58,829
  • SCHEER, Bradley W., Reg. No. 47,059
Priority Data
63/046,19030.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR ADMINISTERING RECOMBINANT VIRAL VECTORS
(FR) PROCÉDÉS ET COMPOSITIONS POUR L'ADMINISTRATION DE VECTEURS VIRAUX RECOMBINANTS
Abstract
(EN) Provided herein are methods of transducing a recombinant viral, e.g., retroviral, vector, improving the transgene expression from a recombinant viral vector, and reducing titers of neutralizing antibodies that bind a recombinant viral vector. In general, these methods include administering to a subject a recombinant viral vector and an effective amount of an immunosuppressive regimen.
(FR) L'invention concerne des procédés pour la transduction d'un vecteur viral recombinant, par exemple rétroviral, l'amélioration de l'expression transgénique à partir d'un vecteur viral recombinant, et la réduction de titres d'anticorps neutralisants qui se lient à un vecteur viral recombinant. En général, ces procédés comprennent l'administration à un sujet d'un vecteur viral recombinant et d'une quantité efficace d'un régime immunosuppresseur.
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