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1. WO2022006095 - MOSAIC HIV-1 ENVELOPES TO INDUCE ADCC RESPONSES

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Publication Number WO/2022/006095
Publication Date 06.01.2022
International Application No. PCT/US2021/039598
International Filing Date 29.06.2021
IPC
A61K 39/21 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07H 21/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Applicants
  • DUKE UNIVERSITY [US]/[US]
  • TRIAD NATIONAL SECURITY, LLC [US]/[US]
Inventors
  • KORBER, Bette T.
  • GNANAKARAN, Sandrasegaram
  • FERRARI, Guido
  • HAYNES, Barton F.
  • HENDERSON, Rory
Agents
  • ESTRADA DE MARTIN, Paula
Priority Data
63/045,72429.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MOSAIC HIV-1 ENVELOPES TO INDUCE ADCC RESPONSES
(FR) ENVELOPPES MOSAÏQUES DU VIH-1 POUR INDUIRE DES RÉPONSES D'ADCC
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Abstract
(EN) The invention is directed to mosaic human immunodeficiency virus HIV-1 envelopes, and methods of using the same to induce Antibody (Ab)-dependent cellular cytotoxicity (ADCC) responses. Specifically, the disclosure provides new mosaic HIV-1 envelope designs, selection of HIV-1 envelopes and combinations thereof; methods of using these envelopes to induce antibody protective responses, wherein the protective responses are associated with ADCC activity. Further provided are mosaic HIV-1 envelope sequences, and a pharmaceutical composition comprising a polypeptide of any one of the envelopes or a nucleic acid encoding any one of the envelopes disclosed.
(FR) La présente invention concerne des enveloppes mosaïques du VIH-1, et des méthodes d'utilisation de celles-ci pour induire des réponses d'ADCC.
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