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1. WO2022005957 - DEVICES AND METHODS FOR GENOMIC STRUCTURAL ANALYSIS

Publication Number WO/2022/005957
Publication Date 06.01.2022
International Application No. PCT/US2021/039348
International Filing Date 28.06.2021
IPC
C12Q 1/6816 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
C12Q 1/6869 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
C12Q 1/6806 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Applicants
  • DIMENSIONGEN [GB]/[GB]
  • DIMENSION GENOMICS INC [US]/[US]
Inventors
  • AUSTIN, Michael T.
  • RIDGEWAY, William
Agents
  • ANDERSON, Garrett H.
Priority Data
63/046,06930.06.2020US
63/143,85731.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DEVICES AND METHODS FOR GENOMIC STRUCTURAL ANALYSIS
(FR) DISPOSITIFS ET PROCÉDÉS D'ANALYSE STRUCTURALE GÉNOMIQUE
Abstract
(EN) Disclosed are methods for generating physical maps from feature density profiles of a nucleic acid using a constriction device, and associated methods of analyzing said genomic profiles. In addition, disclosed are devices and methods for analyzing secondary, tertiary and quaternary structures on nucleic acids in spatial and temporal context of the 3-D organization of the genome in a constriction or sensor device.
(FR) L'invention concerne des procédés de génération de cartes physiques à partir de profils de densité de caractéristiques d'un acide nucléique à l'aide d'un dispositif de constriction, et des procédés associés d'analyse desdits profils génomiques. De plus, l'invention concerne des dispositifs et des procédés pour analyser des structures secondaires, tertiaires et quaternaires sur des acides nucléiques dans un contexte spatial et temporel de l'organisation 3D du génome dans un dispositif de constriction ou de capteur.
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