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1. WO2022005926 - MODIFIED RELEASE FORMULATIONS OF MODIFIED FORMS OF TRIMETAZIDINE

Publication Number WO/2022/005926
Publication Date 06.01.2022
International Application No. PCT/US2021/039303
International Filing Date 28.06.2021
IPC
A01N 43/04 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04with one hetero atom
A61K 31/675 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants
  • IMBRIA PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • LEVIN, Andrew, D.
  • PATEL, Jaikrishna
  • MOONEY, George
  • HERBIG, Scott
Agents
  • SCHOEN, Adam, M.
  • HYDE, Zachary, D.
  • NICKAS, Mark
  • DIBERNARDO, Ian, G.
  • MEYERS, Thomas, C.
Priority Data
63/046,11530.06.2020US
63/046,11730.06.2020US
63/183,29403.05.2021US
63/183,29903.05.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MODIFIED RELEASE FORMULATIONS OF MODIFIED FORMS OF TRIMETAZIDINE
(FR) FORMULATIONS À LIBÉRATION MODIFIÉE DE FORMES MODIFIÉES DE TRIMÉTAZIDINE
Abstract
(EN) The invention provides pharmaceutical compositions that contain modified release formulations of modified forms of trimetazidine, such as CV-8972. The compositions include an erodible polymer, such as hydroxypropyl methylcellulose (HPMC), that allows sustained release of the modified form of trimetazidine and it metabolic products in the body. The invention also provides methods of treating conditions, including angina and heart failure, using such compositions.
(FR) L'invention concerne des compositions pharmaceutiques qui contiennent des formulations à libération modifiée de formes modifiées de trimétazidine, telles que CV-8972. Les compositions comprennent un polymère érodable, tel que l'hydroxypropylméthylcellulose (HPMC), qui permet une libération prolongée de la forme modifiée de trimétazidine et de ses produits métaboliques dans le corps. L'invention concerne également des méthodes de traitement de pathologies, notamment d'une angine et d'une insuffisance cardiaque, à l'aide de ces compositions.
Latest bibliographic data on file with the International Bureau