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1. WO2022005891 - COMPOSITIONS AND METHODS FOR REPROGRAMMING SKIN TISSUE TO HAVE INSULINOGENIC AND DELIVERY FUNCTIONS

Publication Number WO/2022/005891
Publication Date 06.01.2022
International Application No. PCT/US2021/039083
International Filing Date 25.06.2021
IPC
A61K 38/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/85 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A61P 5/50 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
Applicants
  • THE TRUSTEES OF INDIANA UNIVERSITY [US]/[US]
Inventors
  • SEN, Chandan K.
  • ROY, Sashwati
  • KUMAR, Manishekhar
  • SINGH, Kanhaiya
Agents
  • BREEN, John P.
  • ADDISON, Bradford G.
Priority Data
63/045,44029.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR REPROGRAMMING SKIN TISSUE TO HAVE INSULINOGENIC AND DELIVERY FUNCTIONS
(FR) COMPOSITIONS ET PROCÉDÉS DE REPROGRAMMATION DE TISSU CUTANÉ POUR AVOIR DES FONCTIONS INSULINOGÈNES ET D'ADMINISTRATION
Abstract
(EN) Disclosed herein are compositions and in vitro and in vivo methods for reprogramming post-natal (adult and juvenile) tissue into insulinogenic cells. These compositions and methods are useful for a variety of purposes, including the development of diabetes therapies.
(FR) L'invention concerne des compositions et des méthodes in vitro et in vivo pour la reprogrammation de tissu d'origine post-natale (adulte et juvénile) dans des cellules insulinogènes. Ces compositions et ces méthodes sont utiles à diverses fins, y compris le développement de thérapies contre le diabète.
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