WO2022005590 A METHOD FOR THE DEGRADATION OF ENDOGENOUS PROTEIN

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Publication Number WO/2022/005590

Publication Date 06.01.2022

International Application No. PCT/US2021/029795

International Filing Date 29.04.2021

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CPC

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Applicants

UNIVERSITY OF SOUTH CAROLINA [US]/[US]

Inventors

XU, Peisheng

Agents

LINEBERRY, Douglas L.
THORSON, Chad L.
JOHNSON, III, John E.
QUIRK, Nathaniel T.

Priority Data

17/242,647		28.04.2021		US
63/045,275		29.06.2020		US

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) A METHOD FOR THE DEGRADATION OF ENDOGENOUS PROTEIN

(FR) MÉTHODE DE DÉGRADATION DE PROTÉINE ENDOGÈNE

Abstract

(EN) Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application.

(FR) L'invention concerne des systèmes et des méthodes pour la dégradation de protéine endogène à l'aide d'un nanovecteur, ce qui présente l'avantage d'une mise à l'échelle et d'une faisabilité faciles pour une application in vivo.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69	the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

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1. WO2022005590 - A METHOD FOR THE DEGRADATION OF ENDOGENOUS PROTEIN

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G	MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
69	Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
02	Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
08	derived from amino-carboxylic acids
10	Alpha-amino-carboxylic acids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0019	Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0019	Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0021	Intradermal administration, e.g. through microneedle arrays, needleless injectors

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0019	Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024	Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
007	Pulmonary tract; Aromatherapy
0073	Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;