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1. WO2022005545 - COMPOUNDS AND CONJUGATES OF ZINC FOR PREVENTION AND TREATMENT OF COVID-19 (SARS-COV-2), OTHER VIRAL INFECTIONS, CANCERS

Publication Number WO/2022/005545
Publication Date 06.01.2022
International Application No. PCT/US2021/024797
International Filing Date 30.03.2021
IPC
A61K 33/30 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
30Zinc; Compounds thereof
A61K 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 33/32 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
32Manganese; Compounds thereof
A61K 33/26 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
A61K 33/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
34Copper; Compounds thereof
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • COHEN, David, I. [US]/[US] (US)
Inventors
  • COHEN, David, I.
Agents
  • ACETO, Joseph, F.
Priority Data
63/046,22530.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS AND CONJUGATES OF ZINC FOR PREVENTION AND TREATMENT OF COVID-19 (SARS-COV-2), OTHER VIRAL INFECTIONS, CANCERS
(FR) COMPOSÉS ET CONJUGUÉS DE ZINC POUR LA PRÉVENTION ET LE TRAITEMENT DE LA COVID 19 (SARS-COV-2), D'AUTRES INFECTIONS VIRALES, DE CANCERS
Abstract
(EN) The present invention creates drugs that are both zinc carriers and ionophores, thus capable of delivering zinc intracellularly and in so doing inhibiting COVlD-19 infection. The drug inventions further attack SARS sequelae of COV1D19 infection, such as development of bacterial pneumonias, most prevalent in the elderly, which are attributable to intrapulmonary zinc deficiency. As such, they could be important primary therapies for SARS. The zinc/ionophore porters can be delivered alone, or upon coupling to other antivirals.
(FR) La présente invention permet de créer des médicaments qui sont à la fois des vecteurs de zinc et des ionophores du zinc, permettant ainsi d'administrer du zinc par voie intracellulaire et ce faisant d'inhiber l'infection par la COVlD-19. Les médicaments de l'invention permettent d'attaquer également les séquelles du SRAS de l'infection par la COVID-19, comme le développement de pneumonies bactériennes, les plus répandues chez les personnes âgées, qui sont attribuables à une carence en zinc intrapulmonaire. De ce fait, ces médicaments pourraient faire l'objet de thérapies primaires importantes pour le SRAS. Les porters de zinc/ionophore peuvent être administrés seuls ou lors d'un couplage à d'autres antiviraux.
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