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1. WO2022005503 - STABILIZED CORONAVIRUS SPIKE (S) PROTEIN IMMUNOGENS AND RELATED VACCINES

Publication Number WO/2022/005503
Publication Date 06.01.2022
International Application No. PCT/US2020/053714
International Filing Date 01.10.2020
IPC
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C12N 15/33 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US]
Inventors
  • HE, Linling
  • ZHU, Jiang
  • WILSON, Ian A.
Agents
  • FITTING, Thomas
  • WANG, Hugh
Priority Data
17/019,82514.09.2020US
63/045,55729.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZED CORONAVIRUS SPIKE (S) PROTEIN IMMUNOGENS AND RELATED VACCINES
(FR) IMMUNOGÈNES DE PROTÉINE DE SPICULE (S) DE CORONAVIRUS STABILISÉ ET VACCINS ASSOCIÉS
Abstract
(EN) The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.
(FR) La présente invention concerne des immunogènes dérivés de protéine S de coronavirus soluble modifiés qui sont stabilisés par l'intermédiaire de modifications spécifiques dans les séquences de S solubles de type sauvage. L'invention concerne en outre des vaccins nanoparticulaires qui contiennent les immunogènes S solubles modifiés présentés sur des nanoparticules à autoassemblage. L'invention concerne en outre des séquences polynucléotidiques codant pour les immunogènes modifiés et les vaccins nanoparticulaires. L'invention concerne en outre des procédés d'utilisation des compositions de vaccin dans différentes applications thérapeutiques, par exemple, pour prévenir ou traiter des infections coronavirales.
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