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1. WO2022005462 - POLY-DONOR CD4+ T CELLS EXPRESSING IL-10 AND USES THEREOF

Publication Number WO/2022/005462
Publication Date 06.01.2022
International Application No. PCT/US2020/040372
International Filing Date 30.06.2020
IPC
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/725 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants
  • TR1X, INC. [US]/[US]
Inventors
  • RONCAROLO, Maria, Grazia
  • DE VRIES, Jan, Egbert
Agents
  • YOON, Hayan
  • FLOULDS, Glenn, J.
  • BAILEY, F., Pinar
  • BECKER, Daniel, M.
  • SEQUEIRA, Antonia, A.
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POLY-DONOR CD4+ T CELLS EXPRESSING IL-10 AND USES THEREOF
(FR) LYMPHOCYTES T CD4+ MULTI-DONATEURS CODANT POUR IL-10 ET LEURS UTILISATIONS
Abstract
(EN) The present disclosure provides a population of poly-donor CD4IL-10 cells generated by genetically modifying CD4+ T cells from at least three different T cell donors. Further provided are methods of generating the poly-donor CD4IL-10 cells and methods of using the poly-donor CD4IL-10 cells for immune tolerization, treating GvHD, cancer, and other immune disorders.
(FR) La présente invention concerne une population de lymphocytes T CD4IL-10 multi-donateurs générés par modification génétique de lymphocytes T CD4+ à partir d'au moins trois donateurs de lymphocytes T différents. L'invention concerne en outre des procédés de génération des lymphocytes CDIL-10 multi-donateurs et des procédés d'utilisation des lymphocytes CDIL-10 multi-donateurs pour, l'augmentation de la tolérance immunitaire, le traitement de la GVHD, du cancer et d'autres troubles immunitaires.
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