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1. WO2022005341 - METHOD FOR IMPROVING THE EFFICIENCY AND REDUCING THE SIDE EFFECTS OF A THERAPEUTIC AGENT

Publication Number WO/2022/005341
Publication Date 06.01.2022
International Application No. PCT/RU2021/050195
International Filing Date 01.07.2021
IPC
C12N 15/63 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 49/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61P 43/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants
  • НИКИТИН, Петр Иванович NIKITIN, Petr Ivanovich [RU]/[RU]
Inventors
  • НИКИТИН, Петр Иванович NIKITIN, Petr Ivanovich
Priority Data
202012214203.07.2020RU
Publication Language Russian (ru)
Filing Language Russian (RU)
Designated States
Title
(EN) METHOD FOR IMPROVING THE EFFICIENCY AND REDUCING THE SIDE EFFECTS OF A THERAPEUTIC AGENT
(FR) COMPOSITION ET PROCÉDÉ POUR RÉDUIRE LES EFFETS SECONDAIRES D'UN AGENT THÉRAPEUTIQUE
(RU) СПОСОБ УЛУЧШЕНИЯ ЭФФЕКТИВНОСТИ И СНИЖЕНИЯ ПОБОЧНЫХ ЭФФЕКТОВ ТЕРАПЕВТИЧЕСКОГО АГЕНТА
Abstract
(EN) The invention relates to the field of biomedicine and nanomedicine, and more particularly to compositions and methods for treating and diagnosing diseases using the magnetic delivery of therapeutic agents. The essence of the invention lies in a composition for improving the efficiency and/or reducing the side effects of a therapeutic agent that is delivered to a target with the aid of a magnetic field, said composition being characterized in that it contains at least an antibody against patient blood cells. The technical result achieved by the invention is that of improving the circulation of an agent in the blood stream, providing more efficient delivery of an agent to a target in the body and improving the efficiency with which diseases are treated and diagnosed with the aid of magnetically controlled therapeutic nanoagents.
(FR) L'invention se rapporte au domaine de la bio-médecine et de la nano-médecine, et concerne des compositions et des procédés pour traiter et diagnostiquer des maladies reposant sur l'administration magnétique d'agents thérapeutiques. Cette invention concerne essentiellement une composition pour améliorer l'efficacité et/ou réduire les effets secondaires d'un agent thérapeutique administré vers une cible à l'aide d'un champ magnétique, caractérisée en ce que ladite composition comprend au moins un anticorps contre des cellules sanguines du patient. Le résultat technique de la présente invention consiste en une amélioration de la circulation dans le flux sanguin, de l'efficacité d'administration vers une cible dans l'organisme, et de l'efficacité de traitement et de diagnostic de maladies à l'aide de nano-agents thérapeutiques commandés de manière magnétique.
(RU) Изобретение относится к области биомедицины и наномедицины, в том числе к композициям и способам для лечения и диагностики заболеваний на основе магнитной доставки терапевтических агентов. Сущность изобретения заключается в композиции для улучшения эффективности и/или снижения побочных эффектов терапевтического агента, доставляемого к мишени с помощью магнитного поля, отличающаяся тем, что упомянутая композиция содержит, по крайней мере, антитело против клеток крови пациента. Технический результат при использовании изобретения состоит в улучшении циркуляции в кровотоке, эффективности доставки к мишени в организме, и эффективности лечения и диагностики заболеваний с помощью магнитоуправляемых терапевтических наноагентов.
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