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1. WO2022005339 - THERAPEUTIC AND DIAGNOSTIC COMPOSITION BASED ON ANTIBODIES

Publication Number WO/2022/005339
Publication Date 06.01.2022
International Application No. PCT/RU2021/050193
International Filing Date 01.07.2021
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61B 10/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
10Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A61K 9/127 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 31/704 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61K 35/14 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
A61K 35/18 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
18Erythrocytes
Applicants
  • НИКИТИН, Петр Иванович NIKITIN, Petr Ivanovich [RU]/[RU]
Inventors
  • НИКИТИН, Петр Иванович NIKITIN, Petr Ivanovich
Priority Data
202012213803.07.2020RU
Publication Language Russian (ru)
Filing Language Russian (RU)
Designated States
Title
(EN) THERAPEUTIC AND DIAGNOSTIC COMPOSITION BASED ON ANTIBODIES
(FR) COMPOSITION POUR THÉRAPIE ET DIAGNOSTIC À BASE D'ANTICORPS
(RU) КОМПОЗИЦИЯ ДЛЯ ТЕРАПИИ И ДИАГНОСТИКИ НА ОСНОВЕ АНТИТЕЛ
Abstract
(EN) The invention relates to the field of biomedicine and nanomedicine, and more particularly to compositions and methods for treating and diagnosing diseases using lipid-containing medicinal agents, as well as compositions and methods for improving the circulation of said agents in the bloodstream and the delivery thereof to targets, and also improving the therapeutic and/or diagnostic efficiency of lipid-containing medicinal agents. The essence of the invention lies in a composition for use in a method for the therapy or diagnosis of diseases or conditions of the body, which includes at least (i) an antibody against patient blood cells which is in a free molecular form, and (ii) a lipid-containing medicinal agent. The technical result achieved by the invention is that of improving the circulation of an agent in the blood stream, providing more efficient delivery of an agent to a target in the body and improving the efficiency with which diseases are treated and diagnosed with the aid of lipid-containing medicinal agents.
(FR) L'invention se rapporte au domaine de la bio-médecine et de la nano-médecine, et concerne notamment des compositions et des procédés pour traiter et diagnostiquer des maladies à l'aide d'agents médicamenteux contenant des lipides, ainsi que des compositions et des procédés d'amélioration de la circulation du flux sanguin, d'administration vers des cibles, et de l'efficacité thérapeutique et/ou diagnostique des agents médicamenteux contenant des lipides. Cette invention concerne essentiellement une composition que l'on utilise dans un procédé de thérapie ou de diagnostic de maladies ou d'états de l'organisme, laquelle comprend au moins i) un anticorps avec une forme moléculaire libre contre les cellules sanguines du patient, et ii) un agent médicamenteux contenant un lipide. Le résultat technique de la présente invention consiste en une amélioration de la circulation dans le flux sanguin, de l'efficacité de traitement et de diagnostic de maladies à l'aide d'agents médicamenteux contenant des lipides.
(RU) Изобретение относится к области биомедицины и наномедицины, в том числе к композициям и способам для лечения и диагностики заболеваний на основе липид-содержащих лекарственных агентов, а также композиций и способов улучшения циркуляции в кровотоке, доставки к мишеням, а также терапевтической и/или диагностической эффективности липид-содержащих лекарственных агентов. Сущность изобретения заключается в композиции для использования в методе терапии или диагностики заболеваний или состояний организма, включающая в себя, по крайней мере, i) антитело в свободной молекулярной форме против клеток крови пациента, и ii) липид-содержащий лекарственный агент. Технический результат при использовании изобретения состоит в улучшении циркуляции в кровотоке, эффективности доставки к мишени в организме, и эффективности лечения и диагностики заболеваний с помощью липид-содержащих лекарственных агентов.
Latest bibliographic data on file with the International Bureau