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1. WO2022005252 - NOVEL PROTAC CHIMERIC COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING, AMELIORATING, OR TREATING DISEASES THROUGH TARGET PROTEIN DEGRADATION

Publication Number WO/2022/005252
Publication Date 06.01.2022
International Application No. PCT/KR2021/008437
International Filing Date 02.07.2021
IPC
C07K 7/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
C07K 5/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 포항공과대학교 산학협력단 POSTECH ACADEMY-INDUSTRY FOUNDATION [KR]/[KR]
Inventors
  • 임현석 LIM, Hyun Suk
  • 이영주 LEE, Yeong Ju
Agents
  • 특허법인 이룸리온 ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2020-008137302.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL PROTAC CHIMERIC COMPOUND, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING, AMELIORATING, OR TREATING DISEASES THROUGH TARGET PROTEIN DEGRADATION
(FR) NOUVEAU COMPOSÉ PROTAC CHIMÈRE, ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT POUR PRÉVENIR, SOULAGER OU TRAITER DES MALADIES PAR DÉGRADATION DE PROTÉINE CIBLE
(KO) 신규한 프로탁 키메라 화합물, 이를 포함하는 표적 단백질 분해를 통한 질환의 예방, 개선 또는 치료용 약학적 조성물.
Abstract
(EN) The present invention relates to a novel class of a chimeric molecule associated with a chimeric compound design for degrading a desired target protein, SRC-1. More specifically, the present invention relates to a peptide compound for degrading SRC-1 protein, and a pharmaceutical composition for preventing or treating cancer metastasis and occurrence caused by SRC-1 overexpression, and for preventing or treating immune-related diseases.
(FR) La présente invention concerne une nouvelle classe d'une molécule chimère associée à une conception de composé chimère pour dégrader une protéine cible souhaitée, SRC-1. Plus particulièrement, la présente invention concerne un composé peptidique pour la dégradation de la protéine SRC-1, et une composition pharmaceutique pour prévenir ou traiter les métastases cancéreuses et l'apparition provoquées par la surexpression de SRC-1, et pour prévenir ou traiter des maladies liées au système immunitaire.
(KO) 본 발명은 원하는 표적 단백질인 SRC-1을 분해하기 위한 키메라 화합물 디자인에 관한 새로운 클래스의 키메라 분자 발명이다. 보다 상세하게는 SRC-1 단백질을 분해하기 위한 펩타이드 화합물, SRC-1 과발현으로 발생하는 암 전이 및 발생의 예방 또는 치료, 면역 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.
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