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1. WO2022005228 - PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING 3-KETOACYL-COA THIOLASE INHIBITOR AND CARNITINE ACYLCARNITINE CARRIER INHIBITOR

Publication Number WO/2022/005228
Publication Date 06.01.2022
International Application No. PCT/KR2021/008362
International Filing Date 01.07.2021
IPC
A61K 31/495 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/4439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 국립암센터 NATIONAL CANCER CENTER [KR]/[KR]
Inventors
  • 김수열 KIM, Sooyoul
Agents
  • 파도특허법인(유한) PADO IP LAW PLLC
Priority Data
10-2020-008097301.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING 3-KETOACYL-COA THIOLASE INHIBITOR AND CARNITINE ACYLCARNITINE CARRIER INHIBITOR
(FR) COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER COMPRENANT UN INHIBITEUR DE LA 3-CÉTOACYL-COA THIOLASE ET UN INHIBITEUR DES TRANSPORTEURS DE LA CARNITINE ACYLCARNITINE
(KO) 3-케토아실 COA 타이올레이스 억제제 및 카르니틴 아실카르니틴 운반자 억제제를 포함하는 암 예방 또는 치료용 약학적 조성물
Abstract
(EN) The present invention relates to a pharmaceutical composition for preventing or treating cancer and an anticancer adjuvant, the pharmaceutical composition comprising a 3-ketoacyl-CoA thiolase inhibitor and a carnitine acylcarnitine carrier inhibitor. The composition of the present invention comprising a 3-ketoacyl-CoA thiolase inhibitor and a carnitine acylcarnitine carrier inhibitor can significantly reduce cancer cell growth, oxygen consumption and tumor size compared to a case in which the 3-ketoacyl-CoA thiolase inhibitor or the carnitine acylcarnitine carrier inhibitor is used alone, and thus can be provided as an effective combination anticancer agent.
(FR) La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement du cancer et un adjuvant anticancéreux, la composition pharmaceutique comprenant un inhibiteur de la 3-cétoacyl-CoA thiolase et un inhibiteur des transporteurs de la carnitine acylcarnitine. La composition de la présente invention comprenant un inhibiteur de la 3-cétoacyl-CoA thiolase et un inhibiteur des transporteurs de la carnitine acylcarnitine peut réduire significativement la prolifération des cellules cancéreuses, la consommation d'oxygène et la taille des tumeurs par rapport à ce que l'on observe lorsque l'inhibiteur de la 3-cétoacyl-CoA thiolase ou l'inhibiteur des transporteurs de la carnitine acylcarnitine est utilisé seul, et peut ainsi constituer un agent anticancéreux combiné efficace.
(KO) 본 발명은 3-케토아실 CoA 타이올레이스 억제제 및 카르니틴 아실카르니틴 운반자 억제제를 포함하는 암 예방 또는 치료용 약학적 조성물 및 항암보조제에 대한 것이다. 본 발명의 3-케토아실 CoA 타이올레이스 억제제 및 카르니틴 아실카르니틴 운반자 억제제를 포함하는 조성물은 3-케토아실 CoA 타이올레이스 억제제 또는 카르니틴 아실카르니틴 운반자 억제제를 각각 단독으로 사용하는 경우에 비하여 암세포의 성장, 산소 소비량 내지 종양의 크기가 유의적으로 감소하므로, 효과적인 병용 항암제로서 제공될 수 있다.
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