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1. WO2022005155 - NOVEL ATELOCOLLAGEN AND USE THEREOF

Publication Number WO/2022/005155
Publication Date 06.01.2022
International Application No. PCT/KR2021/008154
International Filing Date 29.06.2021
IPC
C07K 14/78 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
A61K 47/42 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 인터올리고 주식회사 INTEROLIGO CORPORATION. [KR]/[KR]
Inventors
  • 이중환 LEE, Jung Hwan
  • 이세나 LEE, Se Na
  • 김도영 KIM, Do Young
  • 이다경 LEE, Da Gyeong
  • 이종욱 LEE, Jong Ook
  • 최지아 CHOI, Ji Ah
Agents
  • 특허법인리채 LEECHAE INTELLECTUAL PROPERTY
Priority Data
10-2020-007922429.06.2020KR
10-2021-008460929.06.2021KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL ATELOCOLLAGEN AND USE THEREOF
(FR) NOUVEL ATÉLOCOLLAGÈNE ET SON UTILISATION
(KO) 신규 아텔로콜라겐 및 그의 용도
Abstract
(EN) The present invention relates to a novel atelocollagen and to a use thereof, and more particularly, the atelocollagen has a characteristic that the peak area for a β chain (Sβ) is larger than the second peak area for an α chain (Sα2) when being analyzed by high performance liquid chromatography (HPLC), such that once a physiologically active material is impregnated, the atelocollagen can reduce a rapid initial release of the physiologically active material in the body, or control a decrease in the effect of the physiologically active material due to too slow of an initial release. In addition, the atelocollagen of the present invention may exhibit an excellent cancer metastasis inhibitory effect.
(FR) La présente invention concerne un nouvel atélocollagène et son utilisation, et plus précisément l'atélocollagène présente une caractéristique selon laquelle l'aire du pic pour une chaîne β (Sβ) est plus grande que l'aire du second pic pour une chaîne α (Sα2) lorsque l'analyse est effectuée par une chromatographie en phase liquide hautes performances (CLHP), de sorte que, une fois qu'une matière physiologiquement active est imprégnée, l'atélocollagène peut réduire une libération initiale rapide de la matière physiologiquement active dans le corps, ou maîtriser une diminution de l'effet de la matière physiologiquement active en raison d'une libération initiale trop lente. En outre, l'atélocollagène de la présente invention peut présenter un excellent effet d'inhibition des métastases cancéreuses.
(KO) 본 발명은 신규 아텔로콜라겐 및 그의 용도에 관한 것으로, 보다 상세하게는 상기 아텔로콜라겐은 고성능 액체 크로마토그래피(HPLC) 분석 시 상기 β 사슬에 대한 피크 면적(Sβ)이 상기 α 사슬에 대한 두 번째 피크 면적(Sα2)보다 큰 특징을 가짐으로써 생리활성물질을 담지하면 체내에서 생리활성물질의 급격한 초기 방출을 저하시키거나, 너무 느린 초기 방출로 인한 생리활성물질의 효과 감소를 조절할 수 있다. 또한 본 발명의 아텔로콜라겐은 우수한 암 전이 억제 효과를 나타낼 수 있다.
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