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1. WO2022005117 - ANTI-SARS-COV-2 S PROTEIN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SARS-COV-2 INFECTION COMPRISING SAME

Publication Number WO/2022/005117
Publication Date 06.01.2022
International Application No. PCT/KR2021/008023
International Filing Date 25.06.2021
IPC
C07K 16/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C12N 15/85 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • 앱클론(주) ABCLON INC. [KR]/[KR]
Inventors
  • 이종서 LEE, Jong-Seo
  • 이영하 LEE, Young-Ha
  • 이종호 LEE, Jong-Ho
  • 이현종 LEE, Hyun-Jong
Agents
  • 공병욱 KONG, Byung Wook
Priority Data
10-2020-008117901.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) ANTI-SARS-COV-2 S PROTEIN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SARS-COV-2 INFECTION COMPRISING SAME
(FR) ANTICORPS ANTI-PROTÉINE S DU SARS-COV-2 OU FRAGMENT DE LIAISON À L'ANTIGÈNE DE CELUI-CI, ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE INFECTION À SARS-COV-2 LE COMPRENANT
(KO) 항-SARS-CoV-2 S 단백질 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 SARS-CoV-2 감염증의 예방 또는 치료용 약제학적 조성물
Abstract
(EN) The present invention relates to an anti-SARS-CoV-2 S protein antibody or antigen-binding fragment thereof, and a pharmaceutical composition for treating COVID-19 comprising same. The anti-SARS-CoV-2 S protein antibody or antigen-binding fragment thereof of the present invention can be usefully used as a therapeutic agent for COVID-19 since the same binds specifically to a S protein, which plays an important role in the infiltration of SARS-CoV-2 into host cells, so as to inhibit infection with SARS-CoV-2.
(FR) La présente invention concerne un anticorps anti-protéine S du SARS-CoV-2 ou un fragment de liaison à l'antigène de celui-ci, et une composition pharmaceutique pour le traitement de la COVID-19 le comprenant. L'anticorps anti-protéine S du SARS-CoV-2 ou le fragment de liaison à l'antigène de celui-ci selon la présente invention peut être utilisé de manière utile en tant qu'agent thérapeutique contre la COVID-19 puisqu'il se lie spécifiquement à une protéine S, qui joue un rôle important dans l'infiltration du SARS-CoV-2 dans des cellules hôtes, de manière à inhiber une infection à SARS-CoV-2.
(KO) 본 발명은 항-SARS-CoV-2 S 단백질 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 COVID-19 치료용 약제학적 조성물에 관한 것이다. 본 발명의 항-SARS-CoV-2 S 단백질 항체 또는 그의 항원 결합 단편은 SARS-CoV-2의 숙주세포 내 침투에 중요한 역할을 수행하는 S 단백질에 특이적으로 결합하여 SARS-CoV-2의 감염을 억제할 수 있으므로, COVID-19의 치료제로서 유용하게 사용될 수 있다.
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