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1. WO2022005035 - NOVEL BIFIDOBACTERIUM BREVE IDCC 4401 STRAIN AND ITS DEAD CELL ID-BBR4401 HAVING EXCELLENT ACID TOLERANCE AND BILE TOLERANCE AND PROPHYLACTIC OR THERAPEUTIC EFFECT ON DYSLIPIDEMIA

Publication Number WO/2022/005035
Publication Date 06.01.2022
International Application No. PCT/KR2021/007117
International Filing Date 08.06.2021
IPC
C12N 1/20 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
A61K 35/74 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
A61P 3/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A23L 33/135 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A23K 10/10 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
KFEEDING-STUFFS SPECIALLY ADAPTED FOR ANIMALS; METHODS SPECIALLY ADAPTED FOR PRODUCTION THEREOF
10Animal feeding-stuffs
10obtained by microbiological or biochemical processes
C12R 1/01 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
01Bacteria or actinomycetales
Applicants
  • 일동제약(주) IL DONG PHARMACEUTICAL CO., LTD. [KR]/[KR]
Inventors
  • 김민구 KIM, Min-Goo
  • 이돈길 LEE, Don-Gil
  • 김태윤 KIM, Tae-Yoon
Agents
  • 이희숙 LEE, Hee Sook
Priority Data
10-2020-008058830.06.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL BIFIDOBACTERIUM BREVE IDCC 4401 STRAIN AND ITS DEAD CELL ID-BBR4401 HAVING EXCELLENT ACID TOLERANCE AND BILE TOLERANCE AND PROPHYLACTIC OR THERAPEUTIC EFFECT ON DYSLIPIDEMIA
(FR) NOUVELLE SOUCHE DE BIFIDOBACTERIUM BREVE IDCC 4401 ET SA CELLULE MORTE ID-BBR4401 AYANT D'EXCELLENTES TOLÉRANCES AUX ACIDES ET À LA BILE ET UN EFFET PROPHYLACTIQUE OU THÉRAPEUTIQUE SUR LA DYSLIPIDÉMIE
(KO) 내산성 및 내담즙성이 우수하며 이상지질혈증의 예방 또는 치료 효과를 가지는 신규 비피도박테리움 브레베 IDCC 4401 균주 및 이의 사균체 ID-BBR4401
Abstract
(EN) The present invention relates to a novel Bifidobacterium breve IDCC 4401 strain (accession number: KCTC13169BP) and its dead cell ID-BBR4401, which are superb in acid tolerance and bile tolerance and have a preventive or therapeutic effect on dyslipidemia. Having not only an excellent effect of reducing a cholesterol level in the body but also a very high level of acid tolerance and bile tolerance in contrast to previously known B. breve, the novel Bifidobacterium breve IDCC 4401 strain (accession number: KCTC13169BP) of the present invention well exhibits the functionality that the strain has in the digestive duct of animals (especially humans), has an excellent growth potential, and provides sustainable and effective functionality of reducing a level of cholesterol in vivo.
(FR) La présente invention concerne une nouvelle souche de Bifidobacterium breve IDCC 4401 (numéro d'enregistrement : KCTC13169BP) et sa cellule morte ID-BBR4401, qui sont exceptionnelles en matière de tolérance à l'acide et à la bile et ont un effet préventif ou thérapeutique sur la dyslipidémie. Ayant non seulement un excellent effet de réduction du taux de cholestérol dans le corps mais également un niveau très élevé de tolérances à l'acide et à la bile par rapport aux B. breve précédemment connues, la nouvelle souche de Bifidobacterium breve IDCC 4401 (numéro d'accession : KCTC13169BP) de la présente invention présente également la fonctionnalité selon laquelle la souche présente dans le conduit digestif d'animaux (notamment d'êtres humains) a un excellent potentiel de croissance et fournit une fonctionnalité durable et efficace de réduction d'un niveau de cholestérol in vivo.
(KO) 본 발명은 내산성 및 내담즙성이 우수하며 이상지질혈증의 예방 또는 치료 효과를 가지는 신규 비피도박테리움 브레베 IDCC 4401 균주(기탁번호: KCTC13169BP) 및 이의 사균체 ID-BBR4401에 관한 것으로, 본 발명의 신균주 비피도박테리움 브레베 IDCC 4401 균주(기탁번호: KCTC13169BP)는 우수한 체내 콜레스테롤 감소 효과를 가질 뿐만아니라, 기존에 공지된 B. breve들과는 달리 매우 높은 수준의 내산성 및 내담즙성을 가지기 때문에 동물(특히, 인간)의 소화관 내에서 균주가 가지는 기능성을 잘 나타내며 생육하는 능력이 우수하여, 지속적이고 효과적인 체내 콜레스테롤 감소 기능성을 제공한다.
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