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1. WO2022004805 - METHOD FOR STABILIZING BINDING OF ANTIBODY TO NK CELL AND USE THEREOF

Publication Number WO/2022/004805
Publication Date 06.01.2022
International Application No. PCT/JP2021/024808
International Filing Date 30.06.2021
IPC
A61K 47/42 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • 株式会社ガイアバイオメディシン GAIA BIOMEDICINE INC. [JP]/[JP]
Inventors
  • 原田 結 HARADA Yui
  • 米満 吉和 YONEMITSU Yoshikazu
Agents
  • 特許業務法人特許事務所サイクス SIKS & CO.
Priority Data
2020-11308330.06.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR STABILIZING BINDING OF ANTIBODY TO NK CELL AND USE THEREOF
(FR) PROCÉDÉ DE STABILISATION DE LIAISON D'UN ANTICORPS SUR UNE CELLULE NK ET UTILISATION ASSOCIÉE
(JA) NK細胞と抗体との結合を安定化する方法、及びその利用
Abstract
(EN) The present invention addresses the problem of stably binding an antibody onto an NK cell. Provided is a method for stabilizing the binding of an antibody to an NK cell, said method comprising using a substance that has region I capable of binding to a surface protein of the NK cell and region II capable of binding to the antibody. The substance may further contain a linker part for linking, in addition to regions I and II.
(FR) La présente invention aborde le problème de la liaison stable d'un anticorps sur une cellule NK. La présente invention concerne un procédé de stabilisation de la liaison d'un anticorps sur une cellule NK, ledit procédé comprenant l'utilisation d'une substance dotée d'une région I capable de se lier à une protéine de surface de la cellule NK et d'une région II capable de se lier à l'anticorps. La substance peut en outre contenir une partie liant pour la liaison, en plus des régions I et II.
(JA) NK細胞上に抗体を安定的に結合させることを課題とする。NK細胞と抗体との結合を安定化する方法であって、NK細胞の表面タンパク質に結合可能な領域I、抗体に結合可能な領域IIを有する物質を用いる方法を提供する。物質は、領域Iと領域IIと、連結リンカー部をさらに含んでいてもよい。
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