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1. WO2022004765 - COMPOSITION FOR GENOME EDITING

Publication Number WO/2022/004765
Publication Date 06.01.2022
International Application No. PCT/JP2021/024675
International Filing Date 30.06.2021
IPC
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A61K 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 47/30 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • 公益財団法人川崎市産業振興財団 KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION [JP]/[JP]
Inventors
  • 片岡 一則 KATAOKA Kazunori
  • 内田 智士 UCHIDA Satoshi
  • アッバシ サエド アムジャド ヨセフ ABBASI Saed Amjad Yousef
Agents
  • 棚井 澄雄 TANAI Sumio
  • 飯田 雅人 IIDA Masato
  • 宮本 龍 MIYAMOTO Ryu
  • 服部 映美 HATTORI Emi
Priority Data
2020-11343430.06.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOSITION FOR GENOME EDITING
(FR) COMPOSITION POUR L'ÉDITION DU GÉNOME
(JA) ゲノム編集用組成物
Abstract
(EN) A polyion complex including a block copolymer that has a cationic polymer block and a hydrophilic polymer block, an mRNA that encodes a Cas protein, and a guide RNA. A composition for genome editing including the polyion complex, and a pharmaceutical composition.
(FR) Complexe polyionique comprenant un copolymère séquencé qui comporte un bloc polymère cationique et un bloc polymère hydrophile, un ARNm qui code pour une protéine Cas, et un ARN guide. L'invention concerne également une composition pour l'édition du génome, comprenant le complexe polyionique, et une composition pharmaceutique.
(JA) カチオン性ポリマーブロックと親水性ポリマーブロックとを有するブロックコポリマー、Casタンパク質をコードするmRNA、及びガイドRNA、を含む、ポリイオンコンプレックス。前記ポリイオンコンプレックスを含むゲノム編集用組成物、及び医薬組成物。
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