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1. WO2022004094 - MICRO DROPLET FORMATION DEVICE AND ANALYSIS DEVICE

Publication Number WO/2022/004094
Publication Date 06.01.2022
International Application No. PCT/JP2021/015116
International Filing Date 12.04.2021
Chapter 2 Demand Filed 08.10.2021
IPC
B01J 19/10 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
08Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
10employing sonic or ultrasonic vibrations
G01N 1/00 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
G01N 1/28 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
G01N 30/72 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
H01J 49/04 2006.1
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
G01N 27/62 2021.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
Applicants
  • 株式会社日立ハイテク HITACHI HIGH-TECH CORPORATION [JP]/[JP]
  • 本多電子株式会社 HONDA ELECTRONICS CO., LTD. [JP]/[JP]
Inventors
  • 宮坂 徹 MIYASHITA Tooru
  • 柴田 亨 SHIBATA Toru
  • 神田 隆之 KANDA Takayuki
  • 疋田 智美 HIKIDA Tomomi
Agents
  • ポレール特許業務法人 POLAIRE I.P.C.
Priority Data
2020-11235130.06.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) MICRO DROPLET FORMATION DEVICE AND ANALYSIS DEVICE
(FR) DISPOSITIF DE FORMATION DE MICRO-GOUTTELETTES ET DISPOSITIF D'ANALYSE
(JA) 微小液滴形成装置および分析装置
Abstract
(EN) Provided are a micro droplet formation device capable of dividing even small liquid samples, that have been separated by liquid chromatography, into micro droplets with a mean particle diameter of several µm, and an analysis device. A micro droplet device according to the present invention is characterized by comprising: an ultrasonic vibration generation unit (8) that generates ultrasonic vibrations; an ultrasonic vibration propagation and expansion unit (9) that expands and propagates the ultrasonic vibrations generated by the ultrasonic vibration generation unit; a sample excitation vibration unit (3) that imparts vibration on a liquid sample by using the ultrasonic vibrations that have been expanded by the ultrasonic vibration propagation and expansion unit, and forms microdroplets of the liquid sample; and a sample supply unit (40) that continuously supplies the liquid sample to the sample excitation vibration unit, wherein a liquid film formation member is provided on an excitation vibration surface (A) of the sample excitation vibration unit so as to be capable of maintaining the liquid sample, supplied by the sample supply unit, in a liquid film form.
(FR) L'invention concerne un dispositif de formation de micro-gouttelettes capable de diviser même de petits échantillons liquides, qui ont été séparés par chromatographie liquide, en micro-gouttelettes ayant un diamètre moyen de particule de plusieurs µm, et un dispositif d'analyse. Un dispositif à micro-gouttelettes selon la présente invention est caractérisé en ce qu'il comprend : une unité de génération de vibrations ultrasonores (8) qui génère des vibrations ultrasonores ; une unité de propagation et d'expansion de vibrations ultrasonores (9) qui se dilate et propage les vibrations ultrasonores générées par l'unité de génération de vibrations ultrasonores ; une unité de vibration d'excitation d'échantillon (3) qui imprime des vibrations sur un échantillon liquide en utilisant les vibrations ultrasonores qui ont été étendues par l'unité de propagation et d'expansion de vibrations ultrasonores, et forme des micro-gouttelettes de l'échantillon liquide ; et une unité d'alimentation d'échantillon (40) qui fournit en continu l'échantillon liquide à l'unité de vibration d'excitation d'échantillon, un élément de formation de film liquide étant disposé sur une surface de vibration d'excitation (A) de l'unité de vibration d'excitation d'échantillon de manière à pouvoir maintenir l'échantillon liquide, fourni par l'unité d'alimentation d'échantillon, sous forme de film liquide.
(JA) 液体クロマトグラフィで分離された少量の液体試料でも、平均粒径が数μmの微小液滴に分割することが可能な微小液滴形成装置および分析装置を提供する。 本発明の微小液滴装置は、超音波振動を発生する超音波振動発生部(8)と、超音波振動発生部で発生した超音波振動を拡大しながら伝達する超音波振動伝達拡大部(9)と、超音波振動伝達拡大部で拡大された超音波振動で液体試料を加振し、液体試料の微小液滴を形成する試料加振振動部(3)と、試料加振振動部に前記液体試料を連続的に供給する試料供給部(40)と、を備え、試料加振振動部の加振振動面(A)に、試料供給部から供給された液体試料を液膜状に保持可能な液膜形成部材が設けられていることを特徴とする。
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