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1. WO2022003693 - ANTI-TUMOR NECROSIS FACTOR RECEPTOR (TNFR2) ANTIBODIES AND USES THEREOF

Publication Number WO/2022/003693
Publication Date 06.01.2022
International Application No. PCT/IL2021/050810
International Filing Date 01.07.2021
IPC
C07K 39/395
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12P 21/08 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
C12N 15/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C07H 21/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
Applicants
  • BIOLOJIC DESIGN LTD. [IL]/[IL]
Inventors
  • LEVIN, Itay
  • NIMROD, Guy
  • INBAR, Amit
  • CHEN, Ayelet
  • VANA, Tal
  • LEVITIN, Natalie
  • OREN, Nino
  • SASSON, Yehezkel
  • FASTMAN, Yair
  • TWITO, Oshrat Shir
  • BITON, Nevet Zur
  • BLUVSHTEIN YERMOLAEV, Olga
  • GROSSMAN, Noam
  • BARAK FUCHS, Reut
  • DEMISHTEIN, Alik
  • STRAJBL, Marek
  • ZHENIN, Michael
  • DANIELPUR, Liron
  • OFRAN, Yanay
  • FISCHMAN, Sharon
Agents
  • COHEN, Mark S.
Priority Data
63/047,51402.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-TUMOR NECROSIS FACTOR RECEPTOR (TNFR2) ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-RÉCEPTEUR DU FACTEUR DE NÉCROSE TUMORALE (TNFR2) ET LEURS UTILISATIONS
Abstract
(EN) The present disclosure describes a number of anti-TNFR2 (Tumor necrosis factor receptor 2) antibodies. These antibodies are tight binders to TNFR2 but are neither agonists nor antagonists. These antibodies can decrease the number of TNFR2+ regulatory T cells or cancer cells through antibody-dependent cellular cytotoxicity. In one embodiment, these antibodies can be used to treat diseases such as cancer or autoimmune diseases.
(FR) La présente invention concerne un certain nombre d'anticorps anti-TNFR2 (récepteur du facteur de nécrose tumorale 2). Ces anticorps sont des liants étanches à TNFR2 mais ne sont ni agonistes ni antagonistes. Ces anticorps peuvent diminuer le nombre de lymphocytes T régulateurs TNFR2 + ou de cellules cancéreuses par une cytotoxicité cellulaire dépendante des anticorps. Dans un mode de réalisation, ces anticorps peuvent être utilisés pour traiter des maladies telles que le cancer ou des maladies auto-immunes.
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