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1. WO2022003662 - LOW BURST-RELEASE LIRAGLUTIDE DEPOT SYSTEMS

Publication Number WO/2022/003662
Publication Date 06.01.2022
International Application No. PCT/IL2021/050479
International Filing Date 26.04.2021
IPC
A61K 38/26 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
C07K 14/605 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • MAPI PHARMA LTD. [IL]/[IL]
Inventors
  • ZATS, Galina
  • BLEICH KIMELMAN, Nadav
  • RUBNOV, Shai
  • MAROM, Ehud
Agents
  • WEBB, Cynthia
  • ARONIS, Zeev
  • BURSTEIN, Tal
  • FINAROV, Igal
  • GANOR, Sharon
  • HORNIK, Vered
  • KAHN, Chanoch
  • NOY, Adi
  • POTASH, Shay
  • RAZ, Sefi
  • SCHICKLER, Hedva
  • SCHVARTZ, Iris
  • TRAVITSKY, Nina
  • WAINSCHTEIN, Silvy
  • ZIPOR, Gadi
Priority Data
63/045,21329.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) LOW BURST-RELEASE LIRAGLUTIDE DEPOT SYSTEMS
(FR) SYSTÈMES DE DÉPÔT DE LIRAGLUTIDE À FAIBLE LIBÉRATION RAPIDE
Abstract
(EN) The present invention provides parenteral pharmaceutical compositions comprising therapeutically effective amounts of liraglutide or pharmaceutically acceptable salts thereof, the parenteral pharmaceutical compositions are formulated in depot form and provide low-burst release in the first twenty-four hours post administration. The present invention further provides methods of use of the parenteral pharmaceutical compositions for treating type-2 diabetes mellitus and Parkinson's disease.
(FR) La présente invention concerne des compositions pharmaceutiques parentérales comprenant des quantités thérapeutiquement efficaces de liraglutide ou de sels pharmaceutiquement acceptables associés, les compositions pharmaceutiques parentérales sont formulées sous forme de dépôt et produisent une faible libération rapide dans les vingt-quatre heures après administration. La présente invention concerne en outre des méthodes d'utilisation des compositions pharmaceutiques parentérales pour le traitement du diabète sucré de type 2 et de la maladie de Parkinson.
Latest bibliographic data on file with the International Bureau